Downregulation of IRS2 in myelodysplastic syndrome: A possible role in impaired hematopoietic cell differentiation

dc.creatorMachado-Neto, JA
dc.creatorFavaro, P
dc.creatorLazarini, M
dc.creatorDuarte, ADS
dc.creatorArchangelo, LF
dc.creatorLorand-Metze, I
dc.creatorCosta, FF
dc.creatorSaad, STO
dc.creatorTraina, F
dc.date2012
dc.dateJUL
dc.date2014-07-30T14:49:31Z
dc.date2015-11-26T17:43:12Z
dc.date2014-07-30T14:49:31Z
dc.date2015-11-26T17:43:12Z
dc.date.accessioned2018-03-29T00:25:14Z
dc.date.available2018-03-29T00:25:14Z
dc.identifierLeukemia Research. Pergamon-elsevier Science Ltd, v. 36, n. 7, n. 931, n. 935, 2012.
dc.identifier0145-2126
dc.identifierWOS:000304353400034
dc.identifier10.1016/j.leukres.2012.03.002
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62488
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62488
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1287525
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionInsulin receptor substrate 2 (IRS2) is an adaptor protein that associates with the receptor of erythropoietin, insulin-like growth factor 1 and thrombopoietin; however, its role is not known in myelodysplasia. We, herein, report a significantly lower IRS2 expression in MDS cells, compared to normal cells. IRS2 expression was reduced in high-risk, compared to low-risk disease, and positively correlated with neutrophil and platelet counts. IRS2 was upregulated during erythroid differentiation of CD34(+) cells from normal donors and low-risk MDS patients and also during erythroid, granulocytic and megakaryocytic differentiation in cell lines. These results suggest that defective IRS2 expression plays a role in the impaired hematopoietic cell differentiation in MDS. (C) 2012 Elsevier Ltd. All rights reserved.
dc.description36
dc.description7
dc.description931
dc.description935
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationLeukemia Research
dc.relationLeuk. Res.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectIRS2
dc.subjectMyelodysplastic syndromes
dc.subjectErythropoietin
dc.subjectInsulin-like growth factor 1
dc.subjectDifferentiation
dc.subjectInsulin-receptor Substrate-2
dc.subject3-kinase Activation
dc.subjectErythropoiesis
dc.subjectExpression
dc.subjectProteins
dc.titleDownregulation of IRS2 in myelodysplastic syndrome: A possible role in impaired hematopoietic cell differentiation
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución