Risperidone - Solid-state characterization and pharmaceutical compatibility using thermal and non-thermal techniques

dc.creatorDaniel, JSP
dc.creatorVeronez, IP
dc.creatorRodrigues, LL
dc.creatorTrevisan, MG
dc.creatorGarcia, JS
dc.date2013
dc.dateSEP 20
dc.date2014-07-30T18:28:05Z
dc.date2015-11-26T17:43:01Z
dc.date2014-07-30T18:28:05Z
dc.date2015-11-26T17:43:01Z
dc.date.accessioned2018-03-29T00:25:01Z
dc.date.available2018-03-29T00:25:01Z
dc.identifierThermochimica Acta. Elsevier Science Bv, v. 568, n. 148, n. 155, 2013.
dc.identifier0040-6031
dc.identifierWOS:000324004500016
dc.identifier10.1016/j.tca.2013.06.032
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71145
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71145
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1287468
dc.descriptionA full solid-state characterization of risperidone was conducted using differential scanning calorimetry (DSC), thermogravimetry (TG), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) to examine its physicochemical properties and polymorphism. The primary aim of this work was to study the compatibility of risperidone with pharmaceutical excipients using DSC to obtain and compare the curves of the active pharmaceutical ingredient (API) and the excipients with their 1:1 (w/w) binary mixtures. These same binary mixtures were turned to room temperature and analyzed by FT-IR combined with principal component analysis (PCA) to evaluate solid-state incompatibilities. The chemical incompatibilities of these samples were verified using a stability-indicating liquid chromatography (LC) method to assay for the API and evaluate the formation of degradation products. All of these methods showed incompatibilities between risperidone and the excipients magnesium stearate, lactose and cellulose microcrystalline. (C) 2013 Elsevier B.V. All rights reserved.
dc.description568
dc.description148
dc.description155
dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.descriptionFundacao de Amparo Pesquisa do Estado de Minas Gerais (FAPEMIG) [APQ 00975-12, APQ 01057-12]
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationThermochimica Acta
dc.relationThermochim. Acta
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectAPI-excipient compatibility
dc.subjectTG
dc.subjectDSC
dc.subjectFT-IR
dc.subjectLiquid chromatography
dc.subjectDosage Forms
dc.subjectExcipients
dc.subjectHydrochloride
dc.subjectFormulations
dc.subjectTablets
dc.subjectDissolution
dc.subjectStability
dc.subjectMixtures
dc.subjectProducts
dc.titleRisperidone - Solid-state characterization and pharmaceutical compatibility using thermal and non-thermal techniques
dc.typeArtículos de revistas


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