Early potential impairment of renal sensory nerves in streptozotocin-induced diabetic rats: role of neurokinin receptors

dc.creatorBoer, PA
dc.creatorRossi, CD
dc.creatorMesquita, FF
dc.creatorGontijo, JAR
dc.date2011
dc.dateMAR
dc.date2014-07-30T17:05:07Z
dc.date2015-11-26T17:42:44Z
dc.date2014-07-30T17:05:07Z
dc.date2015-11-26T17:42:44Z
dc.date.accessioned2018-03-29T00:24:43Z
dc.date.available2018-03-29T00:24:43Z
dc.identifierNephrology Dialysis Transplantation. Oxford Univ Press, v. 26, n. 3, n. 823, n. 832, 2011.
dc.identifier0931-0509
dc.identifierWOS:000287746500010
dc.identifier10.1093/ndt/gfq512
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63634
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63634
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1287391
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground. Electrophysiological studies in the mammalian kidney have identified two major classes of sensory receptors of the afferent renal nerves; chemoreceptors (CR) and mechanoreceptors (MR). The localization of calcitonin gene-related peptide (CGRP) and substance P (SP) in these renal pelvic sensory neurons provides an anatomical basis for a possible functional interaction between the two neuropeptides and SP receptor. The present study was performed to examine the possible changes in the responsiveness of renal sensory SP and CGRP receptors in rats with streptozotocin (STZ)-induced diabetes mellitus. Due to the crucial role of renal pelvic SP and CGRP receptors in the activation of renal sensory neurons by various stimuli, we examined whether the responsiveness of MR or CR activation and the dorsal root ganglia content of neuropeptides and neurokinin 1 receptors (NK(1)R) were altered in diabetic rats compared with non-diabetic rats. Methods. Afferent renal nerve activity (ARNA) was recorded from the peripheral portion of the cut end of one renal nerve branch placed on a bipolar silver wire electrode. T(13) dorsal root ganglia (DRG) immunoreactivity was performed to NK(1)R, SP and CGRP. Results. The results of the current study confirmed that the stimulation of renal MR and CR elicited a renorenal reflex response, and that the renal pelvic administration of SP and CGRP increased ipsilateral ARNA and contralateral urinary sodium excretion with no changes in arterial pressure. We also found a decrease in NK(1)R expression followed by an increase in SP and CGRP levels in the DRG of diabetic rats. The ARNA response, produced by renal pelvic MR and CR stimulation, was found to be significantly attenuated in the STZ-induced diabetic model. Conclusions. These data may indicate a compensatory synthesis and/or abnormal axonal delivery of neurokinins from the cell body to synaptic portions of the neuron as the underlying reason for attenuated ARNA in renal sensory neurons of diabetic rats.
dc.description26
dc.description3
dc.description823
dc.description832
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCNPq [500868/91-3]
dc.descriptionFAPESP [06/52431-1]
dc.languageen
dc.publisherOxford Univ Press
dc.publisherOxford
dc.publisherInglaterra
dc.relationNephrology Dialysis Transplantation
dc.relationNephrol. Dial. Transplant.
dc.rightsfechado
dc.rightshttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dc.sourceWeb of Science
dc.subjectafferent renal nerve activity
dc.subjectchemoreceptors
dc.subjectdiabetes mellitus
dc.subjectmechanoreceptor
dc.subjectneurokinin receptors
dc.subjectGene-related Peptide
dc.subjectDorsal-root Ganglia
dc.subjectAldose Reductase Inhibition
dc.subjectRenin-angiotensin System
dc.subjectAcute Volume Expansion
dc.subjectSubstance-p
dc.subjectAxonal-transport
dc.subjectNeurofilament Phosphorylation
dc.subjectPeripheral-nerve
dc.subjectSodium-excretion
dc.titleEarly potential impairment of renal sensory nerves in streptozotocin-induced diabetic rats: role of neurokinin receptors
dc.typeArtículos de revistas


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