In vitro gentamicin sustained and controlled release from chitosan cross-linked films

dc.creatorCampos, MGN
dc.creatorRawls, HR
dc.creatorInnocentini-Mei, LH
dc.creatorSatsangi, N
dc.date2009
dc.dateFEB
dc.date2014-11-17T21:43:47Z
dc.date2015-11-26T17:42:35Z
dc.date2014-11-17T21:43:47Z
dc.date2015-11-26T17:42:35Z
dc.date.accessioned2018-03-29T00:24:31Z
dc.date.available2018-03-29T00:24:31Z
dc.identifierJournal Of Materials Science-materials In Medicine. Springer, v. 20, n. 2, n. 537, n. 542, 2009.
dc.identifier0957-4530
dc.identifierWOS:000263063300014
dc.identifier10.1007/s10856-008-3611-2
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69387
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69387
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69387
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1287344
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionA novel wound dressing film was investigated for controlled and sustained delivery of gentamicin, while covering and protecting the wound. Chitosan was cross-linked with Hexamethylene 1,6-bis (aminocarboxysulfonate) to prepare the wound dressing films. Cross-linking reaction was required to control the water retention and release of encapsulated gentamicin. Cross-linked films swell less and became more hydrophilic than chitosan film itself. However, this behavior was inversely proportional to the degree of cross-linking. In vitro gentamicin release from the cross-linked films, at physiological conditions of pH and temperature, was studied for 2 weeks. The effects of gentamicin initial concentration and cross-linking ratio on the kinetics of gentamicin release were evaluated. Results showed that the diffusion rate was governed by initial concentration of gentamicin and degree of cross-linking, since higher gentamicin initial concentration and degree of cross-linking promoted the slower release, while lower gentamicin initial concentration and degree of cross-linking promoted the faster one.
dc.description20
dc.description2
dc.description537
dc.description542
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherSpringer
dc.publisherDordrecht
dc.publisherHolanda
dc.relationJournal Of Materials Science-materials In Medicine
dc.relationJ. Mater. Sci.-Mater. Med.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectBlocked Diisocyinate
dc.subjectMicrospheres
dc.subjectDelivery
dc.subjectHydrogels
dc.subjectLinking
dc.subjectGenipin
dc.subjectGel
dc.titleIn vitro gentamicin sustained and controlled release from chitosan cross-linked films
dc.typeArtículos de revistas


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