In vitro evaluation of copaiba oil as a kojic acid skin enhancer

dc.creatorde Oliveira, RVM
dc.creatorOhara, MT
dc.creatorVila, MMDC
dc.creatorGoncalves, MM
dc.date2010
dc.dateAPR-JUN
dc.date2014-11-17T21:31:29Z
dc.date2015-11-26T17:42:32Z
dc.date2014-11-17T21:31:29Z
dc.date2015-11-26T17:42:32Z
dc.date.accessioned2018-03-29T00:24:27Z
dc.date.available2018-03-29T00:24:27Z
dc.identifierBrazilian Journal Of Pharmaceutical Sciences. Univ Sao Paulo, Conjunto Quimicas, v. 46, n. 2, n. 363, n. 370, 2010.
dc.identifier1984-8250
dc.identifierWOS:000281879700024
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69374
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69374
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69374
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1287325
dc.descriptionThe capacity or copaiba oil to act as a skin penetration enhancer for the depigmenting agent kojic acid was evaluated using an in vitro diffusion system with static flux and shed rattlesnake skin membrane, Crotalus durissus terrificus, in saline solution at 34 +/- 2 degrees C as the fluid receptor. The quantities of kojic acid liberated into the fluid receptor were determined by spectrophotometry at 268 nin with intervals of one and a half hours. The membranes, pretreated with copaiba oil at 25% and 50% v/v, gave flux values of 8.0 and 12.7 mu g/cm(2)/h, permeability values of 2.0 and 3.3 cmx10(-4)/h, and promotion factors of 4.1 and 3.7, respectively. These results indicate that copaiba oil, at the two concentrations studied, has the capacity to promote penetration of kojic acid.
dc.description46
dc.description2
dc.description363
dc.description370
dc.languageen
dc.publisherUniv Sao Paulo, Conjunto Quimicas
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationBrazilian Journal Of Pharmaceutical Sciences
dc.relationBraz. J. Pharm. Sci.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectCopaiba oil
dc.subjectKojic acid
dc.subjectSkin penetration/in vitro studies
dc.subjectUV Spectrophotometry
dc.subjectCopaifera-multijuga Hayne
dc.subjectShed Snake Skin
dc.subjectHuber Ex Ducke
dc.subjectPercutaneous Penetration
dc.subjectTransdermal Delivery
dc.subjectChemical-composition
dc.subjectPermeation
dc.subjectGel
dc.titleIn vitro evaluation of copaiba oil as a kojic acid skin enhancer
dc.typeArtículos de revistas


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