Physico-chemical characterization of the inclusion complex between a 2-propen-1-amine derivative and beta-cyclodextrin

dc.creatorDe Souza, AO
dc.creatorAlderete, JB
dc.creatorFaljoni-Alario, A
dc.creatorSilva, CL
dc.creatorDuran, N
dc.date2005
dc.dateSEP
dc.date2014-07-30T14:32:05Z
dc.date2015-11-26T17:41:53Z
dc.date2014-07-30T14:32:05Z
dc.date2015-11-26T17:41:53Z
dc.date.accessioned2018-03-29T00:23:43Z
dc.date.available2018-03-29T00:23:43Z
dc.identifierJournal Of The Chilean Chemical Society. Soc Chilena Quimica, v. 50, n. 3, n. 591, n. 596, 2005.
dc.identifier0717-9324
dc.identifierWOS:000232185900012
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59795
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59795
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1287140
dc.descriptionInclusion complexes and physical mixtures were prepared with isomeric mixture of E/Z (50:50) of 3-(4'-bromo-[1,1'-biphenyl)-4-yl)-3-(4-bromophenyl)-N,N-dimethyl-2-propen-1-amine (BBAP) and beta-cyclodextrin (beta-CD) in different proportions. In this study, theoretical calculations using Molecular Mechanics MM+ force field were applied to predict the structures of the inclusion complexes formed by interaction of BBAP and beta-cyclodextrin. Circular dichroism, differential thermal analysis (DTA), X-ray diffraction and (13)C CP/MAS NMR methods were used to characterize the inclusion complexes and provide information about the stoichiometry of the inclusion complexes. The combined spectroscopy techniques indicate the formation of a complex of BBAP/beta-CD in the molar proportion of 1:1 and 1:2 by co-evaporation and no complexation was detected in the physical mixture of the compounds.
dc.description50
dc.description3
dc.description591
dc.description596
dc.languageen
dc.publisherSoc Chilena Quimica
dc.publisherConcepcion
dc.publisherChile
dc.relationJournal Of The Chilean Chemical Society
dc.relationJ. Chil. Chem. Soc.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectbeta-cyclodextrin
dc.subjectinclusion complexes
dc.subject2-propen-1-amine
dc.subjectCircular-dichroism Spectra
dc.subjectAntimycobacterial Activities
dc.subjectMolecular-mechanics
dc.subjectGamma-cyclodextrin
dc.subjectAlpha-cyclodextrin
dc.subjectSystems
dc.subjectCytotoxicity
dc.subjectDrug
dc.subjectNmr
dc.titlePhysico-chemical characterization of the inclusion complex between a 2-propen-1-amine derivative and beta-cyclodextrin
dc.typeArtículos de revistas


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