Nociceptive behavior induced by mustard oil injection into the temporomandibular joint is blocked by a peripheral non-opioid analgesic and a central opioid analgesic

dc.creatorBonjardim, LR
dc.creatorda Silva, AP
dc.creatorGameiro, GH
dc.creatorTambeli, CH
dc.creatorVeiga, MCFD
dc.date2009
dc.dateJAN
dc.date2014-07-30T14:48:26Z
dc.date2015-11-26T17:40:36Z
dc.date2014-07-30T14:48:26Z
dc.date2015-11-26T17:40:36Z
dc.date.accessioned2018-03-29T00:22:18Z
dc.date.available2018-03-29T00:22:18Z
dc.identifierPharmacology Biochemistry And Behavior. Pergamon-elsevier Science Ltd, v. 91, n. 3, n. 321, n. 326, 2009.
dc.identifier0091-3057
dc.identifierWOS:000263014500009
dc.identifier10.1016/j.pbb.2008.08.001
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61941
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61941
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1286773
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionThe aim of this study was to improve the mustard oil (MO) induced temporomandibular joint (TMJ) nociception model and to investigate the potential analgesic activity of systemic dipyrone and tramadol on the nociceptive behavioral responses induced by injection of low concentrations of the MO into the rat TMJ region. TMJ injection of 2.5% MO produced a significant nociceptive behavior expressed by head flinching and orofacial rubbing. This activity was related to the MO injection since mineral oil (vehicle) did not elicit response. Local application of the lidocaine N-ethyl bromide quaternary salt, QX-314 (2%) and systemic administration of morphine (4 mg/kg) significantly reduced the MO-induced nociceptive responses, validating the nociceptive character of the behaviors. The pretreatment with systemic dipyrone (19, 57 or 95 mg/kg) as well as tramadol (5, 7.5 or 10 mg/kg) was effective in decreasing the nociceptive behavioral responses induced by the injection of MO into the rat TMJ. In conclusion, TMJ injection of low concentrations of MO in rats produces well defined and quantifiable nociceptive behaviors constituting a reliable behavioral model for studying TMJ pain mechanisms and testing analgesic drugs. The results also suggest that dipyrone and tramadol could be effective analgesic options in the management of TMJ pain. (c) 2008 Elsevier Inc. All rights reserved.
dc.description91
dc.description3
dc.description321
dc.description326
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationPharmacology Biochemistry And Behavior
dc.relationPharmacol. Biochem. Behav.
dc.rightsaberto
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectTemporomandibular joint
dc.subjectMustard oil
dc.subjectDipyrone
dc.subjectTramadol
dc.subjectNociceptive behavior
dc.subjectAntinociception
dc.subjectInflammatory Irritant Application
dc.subjectJaw Electromyographic Activity
dc.subjectTension-type Headache
dc.subjectDouble-blind
dc.subjectAntiinflammatory Drugs
dc.subjectReceptor Mechanisms
dc.subjectMuscle-activity
dc.subjectPlasma Extravasation
dc.subjectIntravenous Dipyrone
dc.subjectFormalin Test
dc.titleNociceptive behavior induced by mustard oil injection into the temporomandibular joint is blocked by a peripheral non-opioid analgesic and a central opioid analgesic
dc.typeArtículos de revistas


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