Matrix metallopeptidase 2 activity in tendon regions: effects of mechanical loading exercise associated to anabolic-androgenic steroids

dc.creatorMarqueti, RC
dc.creatorPrestes, J
dc.creatorPaschoal, M
dc.creatorRamos, OHP
dc.creatorPerez, SEA
dc.creatorCarvalho, HF
dc.creatorSelistre-de-Araujo, HS
dc.date2008
dc.dateDEC
dc.date2014-11-17T15:56:29Z
dc.date2015-11-26T17:40:08Z
dc.date2014-11-17T15:56:29Z
dc.date2015-11-26T17:40:08Z
dc.date.accessioned2018-03-29T00:21:47Z
dc.date.available2018-03-29T00:21:47Z
dc.identifierEuropean Journal Of Applied Physiology. Springer, v. 104, n. 6, n. 1087, n. 1093, 2008.
dc.identifier1439-6319
dc.identifierWOS:000260636500018
dc.identifier10.1007/s00421-008-0867-7
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/53335
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/53335
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/53335
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1286639
dc.descriptionMatrix metallopeptidases (MMPs) are responsible for degradation of the extracellular matrix components and tissue remodeling. To achieve a better understanding of AAS effects in rat tendon, MMP-2 activity in the proximal and distal regions of the calcanear tendon (CT) and proximal, intermediate and distal region of superficial (SFT) and deep flexor tendons (DFT) after mechanical load exercise associated with AAS was investigated. Animals were grouped into four groups: sedentary animals (S); sedentary animals with ASS supplementation (S + A); trained animals (T) and trained animals with AAS supplementation (T + A). Analysis of MMP activity in tendon extracts was done by gelatin zymography. Both proximal and distal regions of the calcanear tendon showed the lowest MMP-2 concentration and the highest proportion in MMP-2 active form. The intermediate region of the SFT differed (P < 0.01) from the proximal and distal regions with higher % of active MMP-2 in the sedentary group. The proportion of active MMP-2 decreased in the proximal region of the CT. AAS treatment strongly decreased both MMP-2 concentration and active form in the three regions of the SFT and on the proximal region of the CT, but not on the DFT. The differences in the response to exercise and AAS treatment are a result of distinct metabolism and recruitment of these tendon regions in the exercise program employed in this study.
dc.description104
dc.description6
dc.description1087
dc.description1093
dc.languageen
dc.publisherSpringer
dc.publisherNew York
dc.publisherEUA
dc.relationEuropean Journal Of Applied Physiology
dc.relationEur. J. Appl. Physiol.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectMatrix metallopeptidases (MMPs)
dc.subjectTendon
dc.subjectAnabolic-androgenic steroids (AAS)
dc.subjectExercise training
dc.subjectHuman Achilles-tendon
dc.subjectRat Tendon
dc.subjectProteoglycan Composition
dc.subjectGene-expression
dc.subjectProstate-cancer
dc.subjectCollagen
dc.subjectMetalloproteinases
dc.subjectTissue
dc.subjectInhibitors
dc.subjectPathology
dc.titleMatrix metallopeptidase 2 activity in tendon regions: effects of mechanical loading exercise associated to anabolic-androgenic steroids
dc.typeArtículos de revistas


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