Vaginal heat shock protein expression in symptom-free women with a history of recurrent vulvovaginitis

dc.creatorGiraldo, P
dc.creatorNeuer, A
dc.creatorKorneeva, IL
dc.creatorRibeiro, A
dc.creatorSimoes, JA
dc.creatorWitkin, SS
dc.date1999
dc.dateMAR
dc.date2014-12-02T16:30:27Z
dc.date2015-11-26T17:39:54Z
dc.date2014-12-02T16:30:27Z
dc.date2015-11-26T17:39:54Z
dc.date.accessioned2018-03-29T00:21:30Z
dc.date.available2018-03-29T00:21:30Z
dc.identifierAmerican Journal Of Obstetrics And Gynecology. Mosby-elsevier, v. 180, n. 3, n. 524, n. 529, 1999.
dc.identifier0002-9378
dc.identifier1097-6868
dc.identifierWOS:000079175300004
dc.identifier10.1016/S0002-9378(99)70248-6
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73108
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/73108
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73108
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1286569
dc.descriptionOBJECTIVES: The cause of recurrent vulvovaginitis remains unexplained in most cases. Heat shock protein synthesis is induced under conditions of stress; its presence in vaginal samples from women who were between episodes of recurrent vulvovaginitis thus might reflect a persistent perturbation in the local milieu. STUDY DESIGN: We undertook an evaluation by means of enzyme-linked immunosorbent assay of 60-kd heat shack protein and inducible 70-kd heat shock protein expressions in vaginal wash samples from 24 symptom-free women with a history of recurrent vulvovaginitis and 19 matched control subjects. The samples were also tested for Candida albicans, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, and human papillomavirus by polymerase chain reaction; for bacterial vaginosis by clinical and microbiologic evaluation; and for interleukin 10, interleukin 1, interleukin 8, RANTES, and eotaxin by enzyme-linked immunosorbent assay. RESULTS: The presence of 60-kd heat shock protein was detected in 11 women with recurrent vulvovaginitis (45.8%) and 1 control subject (5.3%, P=.005). Similarly 70-kd heat shock protein was present in 8 patients with recurrent vulvovaginitis (33.3%) and no control subjects (P =.005). The presence of 60-kd heat shock protein and the presence of 70-kd heat shock protein were correlated with each other (P=.02), as were both 60-kd heat shock protein (P =.006) and 70-kd heat shock protein (P =.01) correlated with IL-10. There was no relation between the presence of 60-kd heat shock protein or 70-kd heat shock protein and detection of IL-l, IL-8, or any microorganism. CONCLUSION: The expression of heat shock proteins and IL-10 in the vaginas of women with a history of recurrent vulvovaginitis but not in the vaginas of control subjects suggests the existence of differences in the vaginal milieu between the 2 groups, even when both are without vaginal symptoms.
dc.description180
dc.description3
dc.description1
dc.description524
dc.description529
dc.languageen
dc.publisherMosby-elsevier
dc.publisherNew York
dc.publisherEUA
dc.relationAmerican Journal Of Obstetrics And Gynecology
dc.relationAm. J. Obstet. Gynecol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subject60-kd heat shock protein
dc.subject70-kd heat shock protein
dc.subjectinterleukin 10
dc.subjectrecurrent vulvovaginitis
dc.subjectvaginal immune response
dc.subjectPolymerase Chain-reaction
dc.subjectCandida-albicans
dc.subjectVaginitis
dc.subjectAntibodies
dc.subjectGene
dc.titleVaginal heat shock protein expression in symptom-free women with a history of recurrent vulvovaginitis
dc.typeArtículos de revistas


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