Prevalence of the mutation C677 -> T in the methylene tetrahydrofolate reductase gene among distinct ethnic groups in Brazil

dc.creatorArruda, VR
dc.creatorSiqueira, LH
dc.creatorGoncalves, MS
dc.creatorvon Zuben, PM
dc.creatorSoares, MCP
dc.creatorMenezes, R
dc.creatorAnnichino-Bizzacchi, JM
dc.creatorCosta, FF
dc.date1998
dc.date45474
dc.date2014-12-02T16:30:07Z
dc.date2015-11-26T17:39:04Z
dc.date2014-12-02T16:30:07Z
dc.date2015-11-26T17:39:04Z
dc.date.accessioned2018-03-29T00:20:42Z
dc.date.available2018-03-29T00:20:42Z
dc.identifierAmerican Journal Of Medical Genetics. Wiley-liss, v. 78, n. 4, n. 332, n. 335, 1998.
dc.identifier0148-7299
dc.identifierWOS:000075199200005
dc.identifier10.1002/(SICI)1096-8628(19980724)78:4<332
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70241
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/70241
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70241
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1286366
dc.descriptionVascular disease is a serious public health problem in the industrialized world, and is a frequent cause of death among the adult population of Brazil. Mild hyperhomocysteinemia has been identified as a risk factor for arterial disease, venous thrombosis, and neural tube defects. Individuals homozygous for the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR-T) are found in 5-15% of the general population and have significantly elevated plasma homocysteine levels which represent one of the genetic risk factors for vascular diseases, We have analyzed the prevalence of individuals homozygous for the MTHFR-T in 327 subjects representing the three distinct ethnic groups in Brazil, The prevalence of homozygotes for the mutated allele MTHFR-T was high among persons of Caucasian descent (10%) and considerably lower among Black (1.45%) and Indians persons populations (1.2%). These data suggest that screening for the MTHFR-T allele should help in identifying individuals with a high risk of vascular disease among populations with a heterogeneous background. (C) 1998 Wiley-Liss, Inc.
dc.description78
dc.description4
dc.description332
dc.description335
dc.languageen
dc.publisherWiley-liss
dc.publisherNew York
dc.publisherEUA
dc.relationAmerican Journal Of Medical Genetics
dc.relationAm. J. Med. Genet.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectmethylenetetrahydrofolate reductase gene
dc.subjecthomocysteine
dc.subjectfolic acid
dc.subjectarterial disease
dc.subjectvenous thrombosis
dc.subjectCoronary Heart-disease
dc.subjectNeural-tube Defects
dc.subjectRisk Factor
dc.subjectVascular-disease
dc.subjectMethylenetetrahydrofolate Reductase
dc.subjectMild Hyperhomocysteinemia
dc.subject5,10-methylenetetrahydrofolate Reductase
dc.subjectHomocysteine Metabolism
dc.subjectFolic-acid
dc.subjectThrombosis
dc.titlePrevalence of the mutation C677 -> T in the methylene tetrahydrofolate reductase gene among distinct ethnic groups in Brazil
dc.typeArtículos de revistas


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