Inherited risk factors for thrombophilia in children with nephrotic syndrome

dc.creatorFabri, D
dc.creatorBelangero, VMS
dc.creatorAnnichino-Bizzacchi, JM
dc.creatorArruda, VR
dc.date1998
dc.dateNOV
dc.date2014-12-02T16:30:05Z
dc.date2015-11-26T17:38:44Z
dc.date2014-12-02T16:30:05Z
dc.date2015-11-26T17:38:44Z
dc.date.accessioned2018-03-29T00:20:24Z
dc.date.available2018-03-29T00:20:24Z
dc.identifierEuropean Journal Of Pediatrics. Springer Verlag, v. 157, n. 11, n. 939, n. 942, 1998.
dc.identifier0340-6199
dc.identifierWOS:000076919700015
dc.identifier10.1007/s004310050972
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80559
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/80559
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80559
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1286293
dc.descriptionA hereditary tendency to venous thrombosis rarely results in a spontaneous thrombotic episode before puberty. The acquired hypercoagulability associated with nephrotic syndrome (NS) could, however, coincide with underlying inherited thrombophilia, thereby resulting in a thrombotic event. In order to determine the contribution of inherited prothrombotic conditions to thrombosis in children with NS, we analysed DNA from a cohort of patients with NS for the common genetic risk factors of vascular disease. We evaluated 53 children with NS and 41 paediatric controls for prevalence of the factor V mutation Arg506 --> Gin (factor V Leiden), the prothrombin variant (20210G --> A), and homozigosity for Ala677 --> Val in the methylenetetrahydrofolate reductase gene (MTHFR). Eight thrombo-embolic events were identified in 6 out of 53 (11%)children. Three thrombotic events occurred during NS activity and were associated with systemic infections in two and an arterial puncture in one. An inherited risk factor was identified in seven children, all without thrombosis (two heterozygous for the prothrombin variant and five homozygous for the MTHFR-T). None of the studied inherited risk factors were identified among those with thrombosis. Conclusions These data suggest that inherited thrombophilia is not a strong risk factor for the development of non recurrent thrombosis in children with NS.
dc.description157
dc.description11
dc.description939
dc.description942
dc.languageen
dc.publisherSpringer Verlag
dc.publisherNew York
dc.publisherEUA
dc.relationEuropean Journal Of Pediatrics
dc.relationEur. J. Pediatr.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectthrombo-embolism
dc.subjectnephrotic syndrome
dc.subjectfactor V
dc.subjectgene methylenetetrahydrofolate reductase gene prothrombin gene
dc.subjectActivated Protein-c
dc.subjectFactor-v Leiden
dc.subjectVenous Thrombosis
dc.subjectThromboembolic Complications
dc.subjectProthrombin Gene
dc.subjectArterial-disease
dc.subjectMutation
dc.subjectCommon
dc.subjectPlasma
dc.titleInherited risk factors for thrombophilia in children with nephrotic syndrome
dc.typeArtículos de revistas


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