Film Coating of Nifedipine Extended Release Pellets in a Fluid Bed Coater with a Wurster Insert

dc.creatorde Souza, LFG
dc.creatorNitz, M
dc.creatorTaranto, OP
dc.date2014
dc.date2014-07-30T17:34:57Z
dc.date2015-11-26T17:38:31Z
dc.date2014-07-30T17:34:57Z
dc.date2015-11-26T17:38:31Z
dc.date.accessioned2018-03-29T00:20:09Z
dc.date.available2018-03-29T00:20:09Z
dc.identifierBiomed Research International. Hindawi Publishing Corporation, 2014.
dc.identifier2314-6133
dc.identifier2314-6141
dc.identifierWOS:000333693000001
dc.identifier10.1155/2014/520758
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66952
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66952
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1286227
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe objective of this work was to study the coating process of nifedipine extended release pellets using Opadry and Opadry II, in a fluid bed coater with a Wurster insert. The coating process was studied using a complete experimental design of two factors at two levels for each polymer. The variables studied were the inlet air temperature and the coating suspension flow rate. The agglomerate fraction and coating efficiency were the analyzed response variables. The air temperature was the variable that most influenced the coating efficiency for both polymers. In addition, a study of the dissolution profiles of coated and uncoated pellets using 0.5% sodium lauryl sulfate in simulated gastric fluid without enzymes (pH 1.2) was conducted. The results showed a prolonged release profile for the coated and uncoated pellets that was very similar to the standards established by the U. S. Pharmacopoeia. The drug content and the release profiles were not significantly affected by storage at 40 degrees C and 75% relative humidity. However, when exposed to direct sunlight and fluorescent light (light from fluorescent bulbs), the coated pellets lost only 5% of the drug content, while the uncoated ones lost more than 35%; furthermore, the dissolution profile of the uncoated pellets was faster.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionMaua Institute of Technology (IMT)
dc.descriptionUNICAMP
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherHindawi Publishing Corporation
dc.publisherNew York
dc.publisherEUA
dc.relationBiomed Research International
dc.relationBiomed Res. Int.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectDrug-release
dc.subjectPharmacokinetics
dc.subjectBlends
dc.titleFilm Coating of Nifedipine Extended Release Pellets in a Fluid Bed Coater with a Wurster Insert
dc.typeArtículos de revistas


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