Evaluation of boron-doped diamond electrode for simultaneous voltammetric determination of hydrochlorothiazide and losartan in pharmaceutical formulations

dc.creatorSantos, MCG
dc.creatorTarley, CRT
dc.creatorDall'Antonia, LH
dc.creatorSartori, ER
dc.date2013
dc.dateNOV
dc.date2014-07-30T17:27:54Z
dc.date2015-11-26T17:38:02Z
dc.date2014-07-30T17:27:54Z
dc.date2015-11-26T17:38:02Z
dc.date.accessioned2018-03-29T00:19:41Z
dc.date.available2018-03-29T00:19:41Z
dc.identifierSensors And Actuators B-chemical. Elsevier Science Sa, v. 188, n. 263, n. 270, 2013.
dc.identifier0925-4005
dc.identifierWOS:000326345600035
dc.identifier10.1016/j.snb.2013.07.025
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65769
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65769
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1286107
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionA method for the simultaneous determination of hydrochlorothiazide (HCTZ) and losartan (LOS) in pharmaceutical formulations using differential-pulse voltammetry (DPV) was developed. Two very wellresolved and reproducible oxidation peaks of HCTZ and LOS, with separation of 0.23 V, were obtained in Britton-Robinson (BR) buffer (pH 9.5) using an anodically pretreated boron-doped diamond electrode. Under the optimum analytical experimental conditions, the voltammetric method exhibited linear responses for simultaneous determination of HCTZ and LOS in the concentration range 3.0 x 10(-6) to 7.4 x 10(-5) mol L-1 for both compounds, with detection limits of 1.2 x 10(-6) mol L-1 and 9.5 x 10(-7) MOI respectively. The proposed method was successfully applied in the simultaneous determination of LOS and HCTZ content in pharmaceutical formulations, whose accuracy was attested by good agreement of the results (paired t-test at a 95% confidence level) with those obtained using high performance liquid chromatography (HPLC). (C) 2013 Elsevier B.V. All rights reserved.
dc.description188
dc.description263
dc.description270
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundacao Araucaria
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionUEL
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherElsevier Science Sa
dc.publisherLausanne
dc.publisherSuíça
dc.relationSensors And Actuators B-chemical
dc.relationSens. Actuator B-Chem.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectHydrochlorothiazide determination
dc.subjectLosartan determination
dc.subjectBDD electrode
dc.subjectAnodic pretreatment
dc.subjectVoltammetry
dc.subjectPerformance Liquid-chromatography
dc.subjectCarbon-paste Electrode
dc.subjectElectrochemical Detection
dc.subjectFilm Electrodes
dc.subjectTablets
dc.subjectPotassium
dc.subjectAcid
dc.subjectValidation
dc.subjectNanotubes
dc.subjectProducts
dc.titleEvaluation of boron-doped diamond electrode for simultaneous voltammetric determination of hydrochlorothiazide and losartan in pharmaceutical formulations
dc.typeArtículos de revistas


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