Fibroblast growth factor, estrogen, and prolactin receptor features in different grades of prostatic adenocarcinoma in elderly men

dc.creatorHetzl, AC
dc.creatorMontico, F
dc.creatorLorencini, RM
dc.creatorKido, L
dc.creatorCandido, E
dc.creatorBillis, A
dc.creatorFerreira, U
dc.creatorHa Cagnon, V
dc.date2013
dc.dateMAR
dc.date2014-07-30T17:34:53Z
dc.date2015-11-26T17:37:55Z
dc.date2014-07-30T17:34:53Z
dc.date2015-11-26T17:37:55Z
dc.date.accessioned2018-03-29T00:19:36Z
dc.date.available2018-03-29T00:19:36Z
dc.identifierMicroscopy Research And Technique. Wiley-blackwell, v. 76, n. 3, n. 321, n. 330, 2013.
dc.identifier1059-910X
dc.identifier1097-0029
dc.identifierWOS:000315490300016
dc.identifier10.1002/jemt.22170
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66915
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66915
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1286085
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe objective was to characterize and associate the receptor reactivities of fibroblastic growth factor (FGF)-2, FGF-7, FGF-8, epidermal growth factor (EGF), -actin and vimentin in relation to the androgen receptor (AR), and estrogen receptors (ER and ER), and prolactin receptor in the prostate of elderly men showing low- and high-grade adenocarcinoma. Thirty prostatic samples were taken from 60- to 90-year-old patients without prostatic lesions and with low-grade cancer and high-grade cancer, from the University Hospital, School of Medicine, the State University of Campinas. The results showed that increased FGF-2, FGF-7, and FGF-8 receptor reactivities and decreased AR reactivity were verified in both high- and low-grade cancer. However, the FGF-8 receptor showed greater involvement at the beginning of the malignancy alterations. Increased EGF receptor (EGFR) reactivity and diminished -actin immunohistochemistry were identified in both cancer groups. Also, increased ER, PR, and vimentin receptors were verified in both cancer groups. To conclude, the ER involvement in the reactive stroma activation led to a microenvironment, which was favorable to cancer progression, due to maximizing stromal imbalance. The prolactin could be related to cancer progression due to its interaction with ER action, indicating that this hormone could be a relevant target to prevent the estrogenic effects in the prostatic lesions. Both FGF receptor (FGFR)-2 and FGFR-8 play a fundamental role in the early stages of prostate cancer, suggesting that these molecules could be a promising therapeutic target. The differential localization of the fibroblastic factors between the prostatic epithelium and stroma of elderly men, who presented prostate cancer, could indicate a favorable distinction for tumoral progression. Microsc. Res. Tech. 76:321330, 2013. (c) 2013 Wiley Periodicals, Inc.
dc.description76
dc.description3
dc.description321
dc.description330
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2010/01739-1, 2009/50396-2]
dc.languageen
dc.publisherWiley-blackwell
dc.publisherHoboken
dc.publisherEUA
dc.relationMicroscopy Research And Technique
dc.relationMicrosc. Res. Tech.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectprostate
dc.subjectadenocarcinoma
dc.subjectfibroblast growth factors
dc.subjecthormone steroids
dc.subjectsenescence
dc.subjectRat Ventral Prostate
dc.subjectReactive Stroma
dc.subjectCancer Cells
dc.subjectOpposing Roles
dc.subjectFactors Fgfs
dc.subjectExpression
dc.subjectProgression
dc.subjectCarcinogenesis
dc.subjectMetastasis
dc.subjectInduction
dc.titleFibroblast growth factor, estrogen, and prolactin receptor features in different grades of prostatic adenocarcinoma in elderly men
dc.typeArtículos de revistas


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