Increased susceptibility to Strongyloides venezuelensis infection is related to the parasite load and absence of major histocompatibility complex (MHC) class II molecules

dc.creatorRodrigues, RM
dc.creatorCardoso, CR
dc.creatorGoncalves, ALR
dc.creatorSilva, NM
dc.creatorMassa, V
dc.creatorAlves, R
dc.creatorUeta, MT
dc.creatorSilva, JS
dc.creatorCosta-Cruz, JM
dc.date2013
dc.dateNOV
dc.date2014-07-30T14:33:12Z
dc.date2015-11-26T17:37:50Z
dc.date2014-07-30T14:33:12Z
dc.date2015-11-26T17:37:50Z
dc.date.accessioned2018-03-29T00:19:31Z
dc.date.available2018-03-29T00:19:31Z
dc.identifierExperimental Parasitology. Academic Press Inc Elsevier Science, v. 135, n. 3, n. 580, n. 586, 2013.
dc.identifier0014-4894
dc.identifier1090-2449
dc.identifierWOS:000327283500017
dc.identifier10.1016/j.exppara.2013.09.004
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60039
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60039
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1286065
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIn human and murine models strongyloidiasis induce a Th2 type response. In the current study we investigated the role of different loads of Strongyloides venezuelensis in the immune response raised against the parasite and the participation of the major histocompatibility complex (MHC) class II molecule in the disease outcome in face of the different parasite burden. The C57BL/6 wild type (WT) and MHC II-/- mice were individually inoculated by subcutaneous injection with 500 or 3000 S. venezuelensis L3. The MHC II-/- mice infected with 300013 were more susceptible to S. venezuelensis infection when compared with WT groups, in which the parasite was completely eliminated. The production of Th2 cytokines and specific IgG1 or IgE antibodies against parasite were significantly lowered in MHC II-/- infected mice with different larvae inoculums. The infection of MHC II mice with S. venezuelensis induced slight inflammatory alterations in the small intestine, and these lesions were lower when compared with WT mice, irrespective of the parasite load utilized to infect animals. Finally, we concluded that MHC class II molecules are essential in the immune response against S. venezuelensis mainly when infection occurs with high parasite inoculum. (C) 2013 Elsevier Inc. All rights reserved.
dc.description135
dc.description3
dc.description580
dc.description586
dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherAcademic Press Inc Elsevier Science
dc.publisherSan Diego
dc.publisherEUA
dc.relationExperimental Parasitology
dc.relationExp. Parasitol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectStrongyloides venezuelensis
dc.subjectMHC class II
dc.subjectStrongyloidiasis
dc.subjectImmune response
dc.subjectIntestinal Nematode
dc.subjectImmune-responses
dc.subjectRatti Infection
dc.subjectMice
dc.subjectAntigen
dc.subjectStercoralis
dc.subjectEosinophils
dc.subjectElimination
dc.subjectCells
dc.subjectIl-4
dc.titleIncreased susceptibility to Strongyloides venezuelensis infection is related to the parasite load and absence of major histocompatibility complex (MHC) class II molecules
dc.typeArtículos de revistas


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