Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation

dc.creatorTambeli, CH
dc.creatorYoung, A
dc.creatorLevine, JD
dc.creatorGear, RW
dc.date2003
dc.dateNOV
dc.date2014-11-16T23:40:46Z
dc.date2015-11-26T17:37:39Z
dc.date2014-11-16T23:40:46Z
dc.date2015-11-26T17:37:39Z
dc.date.accessioned2018-03-29T00:19:17Z
dc.date.available2018-03-29T00:19:17Z
dc.identifierPain. Elsevier Science Bv, v. 106, n. 41671, n. 173, n. 179, 2003.
dc.identifier0304-3959
dc.identifierWOS:000186693400023
dc.identifier10.1016/S0304-3959(03)00332-4
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57028
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57028
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57028
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1286008
dc.descriptionWe evaluated the role of spinal glutamate and substance P receptors in noxious stimulus-induced antinociception (NSIA). NSIA was produced by subdermal capsaicin administration in the hind paw of the rat and measured as attenuation of the jaw-opening reflex. NSIA was completely blocked by spinal intrathecal administration of the selective NMDA receptor antagonist LY235959 as well as the mGluR(5) antagonists MPEP and SIB-1757 and partially attenuated by the selective AMPA/kainate receptor antagonist NBQX; however, neither the mGluR(1) receptor antagonist LY367385 nor the NK1 antagonist L-703,606 affected NSIA. These results suggest that NSIA depends on glutamate. released from the central terminals of the primary afferent nociceptors, acting primarily on NMDA and mGluR(5) receptors. Although substance P is also known to be released by similar stimuli, NK1 receptors do not appear to play a role in NSIA. The implications of these findings in the context of a proposed spinal circuit that mediates NSIA are discussed. (C) 2003 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
dc.description106
dc.description41671
dc.description173
dc.description179
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationPain
dc.relationPain
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectglutamate
dc.subjectnoxious stimulus-induced antinociception
dc.subjectNMDA and mGluR(5) receptors
dc.subjectJaw-opening Reflex
dc.subjectAspartate Receptor Antagonist
dc.subjectSubstance-p
dc.subjectRat Model
dc.subjectNeurokinin-1 Receptor
dc.subjectPostoperative Pain
dc.subjectNeuropathic Pain
dc.subjectDorsal Horn
dc.subjectNeurons
dc.subjectCord
dc.titleContribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation
dc.typeArtículos de revistas


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