Reduced expression of systemic proinflammatory and myocardial biomarkers after off-pump versus on-pump coronary artery bypass surgery: A prospective randomized study

dc.creatorSerrano, CV
dc.creatorSouza, JA
dc.creatorLopes, NH
dc.creatorFernandes, JL
dc.creatorNicolau, JC
dc.creatorBlotta, MHSL
dc.creatorRamires, JAF
dc.creatorHueb, WA
dc.date2010
dc.dateJUN
dc.date2014-11-15T03:25:49Z
dc.date2015-11-26T17:35:52Z
dc.date2014-11-15T03:25:49Z
dc.date2015-11-26T17:35:52Z
dc.date.accessioned2018-03-29T00:18:07Z
dc.date.available2018-03-29T00:18:07Z
dc.identifierJournal Of Critical Care. W B Saunders Co-elsevier Inc, v. 25, n. 2, n. 305, n. 312, 2010.
dc.identifier0883-9441
dc.identifierWOS:000278638200022
dc.identifier10.1016/j.jcrc.2009.06.009
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80303
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/80303
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80303
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1285709
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground: The effects of off-pump (OffPCABG) and on-pump (OnPCABG) coronary artery bypass grafting (CABG) on myocardium and inflammation are unclear. Objective: Compare the inflammatory response and myocardial injury from patients (pts) submitted to OffPCABG with those that undergo OnPCABG. Methods: Patients with normal left ventricular function were assigned to OffPCABG (n = 40) and OnPCABG (n = 41). Blood samples were collected before and 24 hours after surgery for determination of creatine kinase (CK)-MB (CK-MB), troponin I (cTnI), interleukin (IL)-6, IL-8, P-selectin, intercellular adhesion molecule (ICAM)-1 and C-reactive protein (CRP). Mortalities were registered at 12 months. Results: Preoperative CK-MB and cTnI levels were 3.1 +/- 0.6 TU and 1.2 +/- 0.5 ng/mL for OffPCABG and 3.0 +/- 0.5 IU and 1.0 +/- 0.2 ng/mL for OnPCABG pts. Postoperative CK-MB and cTnI levels were 13.9 +/- 6.5 IU and 19.0 +/- 9.0 ng/mL for OffPCABG vs 29.5 +/- 11.0 IU and 31.5 +/- 10.1 ng/mL for OnPCABG (P < .01). OffPCABG and OnPCABG pts had similar preoperative IL-6 (10 7 and 9 13 pg/mL), IL-8 (19 +/- 7 and 17 +/- 7 pg/mL), soluble P-selectin (70 +/- 21 and 76 +/- 23 pg/mL), soluble ICAM-1 (117 +/- 50 and 127 +/- 52 ng/mL), and CRP (0.09 +/- 0.05 and 0.11 +/- 0.07 mg/L). At 24 hours, for OffPCABG and OnPCABG: IL-6 was 37 +/- 38* and 42 +/- 41*(,dagger) g/mL; IL-8, 33 +/- 31* and 60 +/- 15*(dagger) pg/mL; soluble P-selectin, 99 +/- 26 and 172 +/- 30*(dagger) pg/mL; soluble ICAM-1, 227 +/- 47 and 236 +/- ng/mL; and CRP, 10 +/- 11* and 14 +/- 13*(,dagger) mg/L (*P < .01 vs preoperation; (dagger)P < .01 vs OffPCABG). Increased 24-hour postoperative CRP levels was the only marker to have significant positive correlations with events and occurred just for the OnPCABG pts. In-hospital and 1-year mortalities for the OnPCABG and OffPCABG pts were 2.0% and 2.2% (P = .1) and 2.7% and 4.7% (P = .06), respectively. Conclusions: Thus, the absence of CPB during CABG preserves better the myocardium and attenuates inflammation however, without improving survival. (C) 2010 Published by Elsevier Inc.
dc.description25
dc.description2
dc.description305
dc.description312
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [N. 2002/08301-5]
dc.languageen
dc.publisherW B Saunders Co-elsevier Inc
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationJournal Of Critical Care
dc.relationJ. Crit. Care
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectCardiopulmonary bypass
dc.subjectTroponin
dc.subjectInflammatory markers
dc.subjectOff-pump heart surgery
dc.subjectOn-pump heart surgery
dc.subjectC-reactive protein
dc.subjectCardiopulmonary Bypass
dc.subjectInflammatory Response
dc.subjectGraft-surgery
dc.subjectNeurocognitive Function
dc.subjectCardiac-surgery
dc.subjectHeart-failure
dc.subjectTerm Outcomes
dc.subjectActivation
dc.subjectRevascularization
dc.subjectMortality
dc.titleReduced expression of systemic proinflammatory and myocardial biomarkers after off-pump versus on-pump coronary artery bypass surgery: A prospective randomized study
dc.typeArtículos de revistas


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