Corticosteroid effect upon intestinal and hepatic interleukin profile in a gastroschisis rat model

dc.creatorGoncalves, FLL
dc.creatorBittencourt, DG
dc.creatorVelloso, LA
dc.creatorSchmidt, AF
dc.creatorGallindo, RM
dc.creatorSbragia, L
dc.date2013
dc.date2014-07-30T14:02:48Z
dc.date2015-11-26T17:35:51Z
dc.date2014-07-30T14:02:48Z
dc.date2015-11-26T17:35:51Z
dc.date.accessioned2018-03-29T00:18:07Z
dc.date.available2018-03-29T00:18:07Z
dc.identifierActa Cirurgica Brasileira. Acta Cirurgica Brasileira, v. 28, n. 8, n. 12, 2013.
dc.identifier0102-8650
dc.identifierWOS:000314645100003
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57305
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57305
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1285705
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionPURPOSE: To evaluate the effect of corticosteroids on intestinal and liver interleukin profile in an experimental model of gastroschisis in fetal rats. METHODS: Sprague-Dawley rats at 19.5 days of gestation had its fetuses operated for the creation of gastroschisis. Two groups of fetuses were studied with and without maternal administration of dexamethasone. Each group was composed of fetuses who underwent gastroschisis (G), control fetuses without manipulation (C) and sham fetuses (S). A dosage of the following interleukins was carried out in fetal intestinal and liver tissues: IL-1, IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). The differences between the groups and subgroups were tested by ANOVA with Tukey post-test, with significant values of p<0.05. RESULTS: Dexamethasone led to an increase in intestinal and liver IL-6 (p<0.05) and a decrease in intestinal TNF-alpha (p<0.001) in fetuses with gastroschisis. CONCLUSION: Corticosteroids had an effect on the intestinal interleukin profile and a small effect on the liver interleukin profile due to immunological immaturity of the fetus, and also of fetuses with gastroschisis. The steroid action may not be exclusively anti-inflammatory, but also pro-inflammatory, varying with time of pregnancy.
dc.description28
dc.description1
dc.description8
dc.description12
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2002/02563-8, 2011/00794-1, 2011/12587-0]
dc.languageen
dc.publisherActa Cirurgica Brasileira
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationActa Cirurgica Brasileira
dc.relationActa Cir. Bras.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectGastroschisis
dc.subjectInflammation
dc.subjectDexamethasOne
dc.subjectCytokines
dc.subjectFetal Development
dc.subjectRats
dc.titleCorticosteroid effect upon intestinal and hepatic interleukin profile in a gastroschisis rat model
dc.typeArtículos de revistas


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