The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil

dc.creatorRondon, ES
dc.creatorVieira, AS
dc.creatorValadao, CAA
dc.creatorParada, CA
dc.date2010
dc.date45962
dc.date2014-11-15T02:00:49Z
dc.date2015-11-26T17:35:47Z
dc.date2014-11-15T02:00:49Z
dc.date2015-11-26T17:35:47Z
dc.date.accessioned2018-03-29T00:17:56Z
dc.date.available2018-03-29T00:17:56Z
dc.identifierEuropean Journal Of Pharmacology. Elsevier Science Bv, v. 647, n. 41699, n. 84, n. 89, 2010.
dc.identifier0014-2999
dc.identifierWOS:000283835400011
dc.identifier10.1016/j.ejphar.2010.08.022
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73767
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/73767
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73767
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1285656
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionIntrathecal or epidural administration of NMDA (N-methyl-D-aspartate) receptors antagonists, in special ketamine and ifenprodil are used to control moderate to severe hyperalgesia in humans. Activation of NMDA receptor usually requires binding of two agonists, glutamate and glycine, in different receptor subunits. Ketamine is a NMDA receptor antagonist and acts at phencyclidine site in NR1 subunit while ifenprodil is a selective NR2B subunit antagonist of NMDA receptor. The aim of this study was to investigate the pharmacological interactions between ketamine or its isomers and ifenprodil, when intrathecally co-administrated, to reduce prostaglandin E(2)-induced hyperalgesia in rat's hind paw. The intrathecal administration of ketamine, its isomers R(-) or S(+), or ifenprodil-induced anti-hyperalgesic effects in a dose-related manner. Ifenprodil, in a dose that did not induce significant effect when administrated alone, significantly improved the anti-hyperalgesic effect of ketamine or its isomers. The other way round, ketamine or S(+) ketamine, but not R(-) ketamine, in a dose that did not induce significant effect when administrated alone, improved the anti-hyperalgesic effect of ifenprodil. However, by comparing ED(50)s (half maximal effective doses), ifenprodil-induced potentiation of ketamine was significantly greater than ketamine-induced potentiation of ifenprodil. The findings of this present study suggest that intrathecal administration of very small doses of ifenprodil, just before and ketamine significantly improves its anti-hyperalgesic effect and this association could be useful to control inflammatory pain with less undesirable effects. (c) 2010 Elsevier B.V. All rights reserved.
dc.description647
dc.description41699
dc.description84
dc.description89
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectAnalgesia
dc.subjectInflammatory pain
dc.subjectKetamine
dc.subjectIfenprodil
dc.subject(Rat)
dc.subjectD-aspartate Receptor
dc.subjectNmda-receptor
dc.subjectDorsal-horn
dc.subjectIntravenous Ketamine
dc.subjectClinical-experience
dc.subjectPrimary Afferents
dc.subjectNeuropathic Pain
dc.subjectWind-up
dc.subjectRats
dc.subjectAntagonist
dc.titleThe improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil
dc.typeArtículos de revistas


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