Blood flow and oxygenation changes due to low-frequency repetitive transcranial magnetic stimulation of the cerebral cortex

dc.creatorMesquita, RC
dc.creatorFaseyitan, OK
dc.creatorTurkeltaub, PE
dc.creatorBuckley, EM
dc.creatorThomas, A
dc.creatorKim, MN
dc.creatorDurduran, T
dc.creatorGreenberg, JH
dc.creatorDetre, JA
dc.creatorYodh, AG
dc.creatorHamilton, RH
dc.date2013
dc.dateJUN
dc.date2014-07-30T13:52:29Z
dc.date2015-11-26T17:35:45Z
dc.date2014-07-30T13:52:29Z
dc.date2015-11-26T17:35:45Z
dc.date.accessioned2018-03-29T00:17:51Z
dc.date.available2018-03-29T00:17:51Z
dc.identifierJournal Of Biomedical Optics. Spie-soc Photo-optical Instrumentation Engineers, v. 18, n. 6, 2013.
dc.identifier1083-3668
dc.identifierWOS:000322341100064
dc.identifier10.1117/1.JBO.18.6.067006
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55783
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55783
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1285639
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionTranscranial magnetic stimulation (TMS) modulates processing in the human brain and is therefore of interest as a treatment modality for neurologic conditions. During TMS administration, an electric current passing through a coil on the scalp creates a rapidly varying magnetic field that induces currents in the cerebral cortex. The effects of low-frequency (1 Hz), repetitive TMS (rTMS) on motor cortex cerebral blood flow (CBF) and tissue oxygenation in seven healthy adults, during/after 20 min stimulation, is reported. Noninvasive optical methods are employed: diffuse correlation spectroscopy (DCS) for blood flow and diffuse optical spectroscopy (DOS) for hemoglobin concentrations. A significant increase in median CBF (33%) on the side ipsilateral to stimulation was observed during rTMS and persisted after discontinuation. The measured hemodynamic parameter variations enabled computation of relative changes in cerebral metabolic rate of oxygen consumption during rTMS, which increased significantly (28%) in the stimulated hemisphere. By contrast, hemodynamic changes from baseline were not observed contralateral to rTMS administration (all parameters, p > 0.29). In total, these findings provide new information about hemodynamic/metabolic responses to low-frequency rTMS and, importantly, demonstrate the feasibility of DCS/DOS for noninvasive monitoring of TMS-induced physiologic effects. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
dc.description18
dc.description6
dc.descriptionNational Institutes of Health [P30 NS045839, K01-NS060995, R01-NS060653, K24-NS058386, R24-HD050836, P41-EB015893]
dc.descriptionFundacio Cellex Barcelona (TD)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionRobert Wood Johnson Foundation/Harold Amos Medical Faculty Development Program
dc.descriptionNeuro-Cognitive Rehabilitation Research Network
dc.descriptionInstitute for Translational Medicine and Therapeutics, Clinical & Translational Science Awards
dc.descriptionTranslational Biomedical Imaging Core at the University of Pennsylvania
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionNational Institutes of Health [P30 NS045839, K01-NS060995, R01-NS060653, K24-NS058386, R24-HD050836, P41-EB015893]
dc.descriptionFAPESP [FAPESP 2012/02500-8]
dc.languageen
dc.publisherSpie-soc Photo-optical Instrumentation Engineers
dc.publisherBellingham
dc.publisherEUA
dc.relationJournal Of Biomedical Optics
dc.relationJ. Biomed. Opt.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjecttranscranial magnetic stimulation
dc.subjectdiffuse optical spectroscopy
dc.subjectdiffuse correlation spectroscopy
dc.subjectbrain function
dc.subjectDiffuse Correlation Spectroscopy
dc.subjectNear-infrared Spectroscopy
dc.subjectSimple Finger Movements
dc.subjectHuman Motor Cortex
dc.subjectCognitive Neuroscience
dc.subjectInterhemispheric Inhibition
dc.subjectSensorimotor Cortex
dc.subjectCortical Activation
dc.subjectWave Spectroscopy
dc.subjectPrefrontal Cortex
dc.titleBlood flow and oxygenation changes due to low-frequency repetitive transcranial magnetic stimulation of the cerebral cortex
dc.typeArtículos de revistas


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