Effects of alcohol and nicotine on the mechanical resistance of bone and bone neoformation around hydroxyapatite implants

dc.creatorSoares, EV
dc.creatorFavaro, WJ
dc.creatorCagnon, VHA
dc.creatorBertran, CA
dc.creatorCamilli, JA
dc.date2010
dc.dateJAN
dc.date2014-11-18T13:58:29Z
dc.date2015-11-26T17:29:21Z
dc.date2014-11-18T13:58:29Z
dc.date2015-11-26T17:29:21Z
dc.date.accessioned2018-03-29T00:16:22Z
dc.date.available2018-03-29T00:16:22Z
dc.identifierJournal Of Bone And Mineral Metabolism. Springer Tokyo, v. 28, n. 1, n. 101, n. 107, 2010.
dc.identifier0914-8779
dc.identifierWOS:000273033000015
dc.identifier10.1007/s00774-009-0115-1
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64075
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/64075
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64075
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1285258
dc.descriptionThe consumption of alcohol or nicotine is harmful to the integrity of bone tissue, hindering or even impeding the fixation and maintenance of bone implants. The aim of the present work was to evaluate the effects of ethanol and nicotine, when consumed alone and simultaneously, on both bone mechanical resistance and bone neoformation around hydroxyapatite implants. Twenty rats were divided into four groups: control (CT), alcohol (A), nicotine (N) and nicotine + alcohol (N + A). After 4 weeks of alcohol and/or nicotine consumption, dense (HAD) and porous (HAP) bodies were respectively implanted in a surgically produced bone defect in the right and left tibiae. After the surgeries, the animals continued to consume alcohol and/or nicotine. After ninety days, the animals were sacrificed and the tibiae and femurs were isolated for histological processing and mechanical assays. All the animals presented newly formed bone tissue close to the HAD and HAP ceramic bodies. The animals of the N + A group presented a smaller volume of neoformed bone. Group A animals presented smaller bone volume around the implants in relation to the animals from group N. Bone resistance to mechanical loads was smallest in animals from the N + A group, followed (in order) by the A and N groups. Thus, it can be concluded that nicotine or alcohol consumption produced negative effects on bone mechanical resistance and on the osteogenesis around the HAD and HAP implants. In addition, the simultaneous consumption of the two substances intensified their harmful effects.
dc.description28
dc.description1
dc.description101
dc.description107
dc.languageen
dc.publisherSpringer Tokyo
dc.publisherTokyo
dc.publisherJapão
dc.relationJournal Of Bone And Mineral Metabolism
dc.relationJ. Bone Miner. Metab.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectBone
dc.subjectAlcohol
dc.subjectNicotine
dc.subjectHydroxyapatite
dc.subjectImplants
dc.subjectCell-proliferation
dc.subjectFemale Rats
dc.subjectConsumption
dc.subjectEthanol
dc.subjectDensity
dc.subjectRepair
dc.subjectAdult
dc.subjectModel
dc.subjectReconstruction
dc.subjectDefects
dc.titleEffects of alcohol and nicotine on the mechanical resistance of bone and bone neoformation around hydroxyapatite implants
dc.typeArtículos de revistas


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