Effects of age on elements of insulin-signaling pathway in central nervous system of rats

dc.creatorFernandes, MLDA
dc.creatorSaad, MJA
dc.creatorVelloso, LA
dc.date2001
dc.dateDEC
dc.date2014-11-18T13:56:53Z
dc.date2015-11-26T17:29:21Z
dc.date2014-11-18T13:56:53Z
dc.date2015-11-26T17:29:21Z
dc.date.accessioned2018-03-29T00:16:21Z
dc.date.available2018-03-29T00:16:21Z
dc.identifierEndocrine. Humana Press Inc, v. 16, n. 3, n. 227, n. 234, 2001.
dc.identifier0969-711X
dc.identifierWOS:000174537500010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64072
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/64072
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64072
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1285257
dc.descriptionInsulin resistance is known to play a pivotal role in type 2 diabetes. Senile individuals, besides being prone to insulin resistance and, consequently, to type 2 diabetes, manifest diseases of the central nervous system (CNS) that may be influenced by disturbances of insulin signaling in the brain, such as memory impairment, Parkinson disease, and Alzheimer disease. We investigated the expression and response to insulin of elements involved in the insulin-signaling pathway in the forebrain cortex and cerebellum of rats ages 1 d to 60 wk. The protein content of insulin receptors and SRC homology adaptor protein (SHC) did not change significantly along the time frame analyzed. However, insulin-induced tyrosine phosphorylation of the insulin receptor and SHC, and the association of SHC/growth factor receptor binding protein-2 (GRB2) decreased significantly from d 1 to wk 60 of life in both types of tissues. Moreover, the expression of SH protein tyrosine phosphatase-2 (SHP2), a tyrosine phosphatase involved in insulin signal transduction and regulation of the insulin signal, decreased significantly with age progression, in both the forebrain cortex and the cerebellum of rats. Thus, elements involved in the insulin-signaling pathway are regulated at the expression and/or functional level in the CNS, and this regulation may play a role in insulin resistance in the brain.
dc.description16
dc.description3
dc.description227
dc.description234
dc.languageen
dc.publisherHumana Press Inc
dc.publisherTotowa
dc.publisherEUA
dc.relationEndocrine
dc.relationEndocrine
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectinsulin
dc.subjectSHC
dc.subjectGRB32
dc.subjectSHP2
dc.subjectcentral nervous system
dc.subjectGrowth-factor-i
dc.subjectReceptor Substrate-1
dc.subjectTyrosine Phosphorylation
dc.subjectPhosphatidylinositol 3-kinase
dc.subjectShc/grb2 Association
dc.subjectSensitive Tissues
dc.subjectMammalian Brain
dc.subjectBeta-subunit
dc.subjectAging Rats
dc.subjectIntact Rat
dc.titleEffects of age on elements of insulin-signaling pathway in central nervous system of rats
dc.typeArtículos de revistas


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