Schistosoma mansoni: In vitro schistosomicidal activity of essential oil of Baccharis trimera (less) DC

dc.creatorde Oliveira, RN
dc.creatorRehder, VLG
dc.creatorOliveira, ASS
dc.creatorMontanari, I
dc.creatorde Carvalho, JE
dc.creatorde Ruiz, ALTG
dc.creatorJeraldo, VDS
dc.creatorLinhares, AX
dc.creatorAllegretti, SM
dc.date2012
dc.dateOCT
dc.date2014-07-30T18:35:38Z
dc.date2015-11-26T17:28:52Z
dc.date2014-07-30T18:35:38Z
dc.date2015-11-26T17:28:52Z
dc.date.accessioned2018-03-29T00:15:56Z
dc.date.available2018-03-29T00:15:56Z
dc.identifierExperimental Parasitology. Academic Press Inc Elsevier Science, v. 132, n. 2, n. 135, n. 143, 2012.
dc.identifier0014-4894
dc.identifierWOS:000309737900006
dc.identifier10.1016/j.exppara.2012.06.005
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71509
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71509
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1285152
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionSchistosomiasis is a chronic parasitic disease caused by the trematode species Schistosomamansoni. Chemotherapy is the only immediate recourse to minimize the prevalence and incidence of this disease worldwide. At present, praziquantel (PZQ) is the drug of choice for the treatment of all forms of schistosomiasis. However, dependence on a single drug is concern because some strains can become resistant. In this context, medicinal plants become potential candidates as sources of new drug prototypes. This study provides findings on the schistosomicidal activity of the essential oil of Baccharis trimera in in vitro assays. During the assays parameters such as motility of adult worms, oviposition, morphological changes on the tegument and especially the mortality rate of adult worms of the BH strain were evaluated. The assays, which were carried out with four concentrations - 24, 48, 91 and 130 mu g/mL - of the essential oil, have shown a promising activity regarding the parameters under study. It was possible to notice a significant decline in the motility of the worms and a mortality rate of 100% 30 h after they had been exposed to the essential oil in the concentration of 130 mu g/mL. Male worms were more susceptible, producing a dose-response effect within a smaller exposition period than female worms. In what refers to morphological changes, the essential oil of B. trimera induced a peeling on the tegument surface, as well as the destruction of tubercles and spines, which resulted in smooth areas on the body surface. The essential oil also caused tegument destruction in female worms, in addition to destruction of the oral and acetabular suckers. It is the first time that the schistosomicidal activity has been reported for essential oil of B. trimera (less) DC. (c) 2012 Elsevier Inc. All rights reserved.
dc.description132
dc.description2
dc.description135
dc.description143
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherAcademic Press Inc Elsevier Science
dc.publisherSan Diego
dc.publisherEUA
dc.relationExperimental Parasitology
dc.relationExp. Parasitol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectBaccharis trimera
dc.subjectEssential oil
dc.subjectIn vitro
dc.subjectSchistosoma mansoni
dc.subjectTreatment
dc.subjectAnticancer Drug Screen
dc.subjectAdult Worms
dc.subjectPraziquantel
dc.subjectLeaves
dc.subjectDracunculifolia
dc.subjectResistance
dc.subjectAsteraceae
dc.titleSchistosoma mansoni: In vitro schistosomicidal activity of essential oil of Baccharis trimera (less) DC
dc.typeArtículos de revistas


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