Isolation and characterization of ellagic acid derivatives isolated from Casearia sylvestris SW aqueous extract with anti-PLA(2) activity

dc.creatorDa Silva, SL
dc.creatorCalgarotto, AK
dc.creatorChaar, JS
dc.creatorMarangoni, S
dc.date2008
dc.dateNOV
dc.date2014-11-17T10:50:49Z
dc.date2015-11-26T17:28:22Z
dc.date2014-11-17T10:50:49Z
dc.date2015-11-26T17:28:22Z
dc.date.accessioned2018-03-29T00:15:30Z
dc.date.available2018-03-29T00:15:30Z
dc.identifierToxicon. Pergamon-elsevier Science Ltd, v. 52, n. 6, n. 655, n. 666, 2008.
dc.identifier0041-0101
dc.identifierWOS:000261013300001
dc.identifier10.1016/j.toxicon.2008.07.011
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60807
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/60807
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60807
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1285039
dc.descriptionThe Casearia sylvestris SW (Flacourtiaceae) is utilized in folk medicine (Brazil and all Latin American) to treat several pathologic processes as inflammation, cancer, microbial infection and snake bites. Studies showed that C sylvestris aqueous extract can inhibit many toxic effects caused by snake venoms (or caused by phospholipase A(2) isolated) from different species, mainly of Bothrops genus. Inhibition of enzymatic and myotoxic activities, decrease of edema formation and increase of the survival rate of rats injected with lethal doses of bothropic venoms are some toxic effects inhibited by C sylvestris. In this study, four ellagic acid derivatives from aqueous extracts of C sylvestris were isolated, characterized, and tested against effects from both total venom and PLA(2) (Asp 49 BthTX-II) from the venom of Bothrops jararacussu. The isolated compounds were as follows: ellagic acid (A), 3'-O-methyl ellagic acid (B), 3,3'-di-O-methyl ellagic acid (C), 3-O-methyl-3', 4'-methylenedioxy ellagic acid (D). The inhibition constant values (Ki) for enzymatic activity, as well the IC50 values found in the edematogenic and myotoxic activities, indicate that the ellagic acid is the best inhibitor of these activities, while compounds C and D are the substances with lowest capacity on inhibiting these same effects. Our results show that the presence of hydroxyls at position 3 or 3' (compounds A and B) increases the capacity of these derivatives on inhibiting these toxic effects. However, the presence of nuethoxyl groups at position 3 or 3' reduced, but did not completely inhibit the capacity of compounds C and D on inhibiting all the toxic effects studied. (c) 2008 Elsevier Ltd. All rights reserved.
dc.description52
dc.description6
dc.description655
dc.description666
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationToxicon
dc.relationToxicon
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectEllagic acid
dc.subjectPLA(2)
dc.subjectBothrops jararacussu
dc.subjectCasearia sylvestris
dc.subjectEnzymatic activity
dc.subjectPhospholipase A(2) Inhibitors
dc.subjectSnake-venom
dc.subjectAntiinflammatory Activities
dc.subjectAristolochic Acid
dc.subjectCrystal-structure
dc.subjectPunica-granatum
dc.subjectVolatile Oils
dc.subjectFlavonoids
dc.subjectNeutralization
dc.subjectInflammation
dc.titleIsolation and characterization of ellagic acid derivatives isolated from Casearia sylvestris SW aqueous extract with anti-PLA(2) activity
dc.typeArtículos de revistas


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