Clinicopathological features and immunohistochemical expression of p53, Ki-67, Mcm-2 and Mcm-5 in proliferative verrucous leukoplakia

dc.creatorGouvea, AF
dc.creatorVargas, PA
dc.creatorColetta, RD
dc.creatorJorge, J
dc.creatorLopes, MA
dc.date2010
dc.dateJUL
dc.date2014-11-16T19:28:33Z
dc.date2015-11-26T17:26:19Z
dc.date2014-11-16T19:28:33Z
dc.date2015-11-26T17:26:19Z
dc.date.accessioned2018-03-29T00:13:30Z
dc.date.available2018-03-29T00:13:30Z
dc.identifierJournal Of Oral Pathology & Medicine. Wiley-blackwell, v. 39, n. 6, n. 447, n. 452, 2010.
dc.identifier0904-2512
dc.identifierWOS:000279449100002
dc.identifier10.1111/j.1600-0714.2010.00889.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/56091
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/56091
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/56091
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1284529
dc.descriptionBackground: Proliferative verrucous leukoplakia (PVL) is a distinct and aggressive type of oral leukoplakia which affects elderly women without risk behavior and presents high rates of malignant transformation. The objective of the present study was to evaluate the clinicopathological characteristics and the distribution of cell proliferation markers, aiming to elucidate the distinct biological behavior of the PVL. Methods: Clinical and microscopical features of 12 patients with PVL were reviewed. Immunohistochemical analysis for p53, Ki-67, Mcm-2 and Mcm-5 were performed and the data were correlated. Results: All patients were women, above 50 years of age, 91.7% were non-smoker and 100% were non-habitual drinker. Alveolar ridge (66.6%), tongue (50%) and buccal mucosa (41.6%) were the most affected sites. Four patients developed squamous cell carcinoma (SCC). The immunohistochemical findings showed higher positivity for p53, Ki-67, Mcm-2 and Mcm-5 in SCCs. However, some patients with mild or moderate dysplasia, specially the patients who developed SCC, presented high expression of Mcm-2 and Mcm-5. Conclusions: High immunoexpression of Mcm-2 and Mcm-5 in mild and moderate dysplasia could be helpful to predict the malignant transformation of PVL.
dc.description39
dc.description6
dc.description447
dc.description452
dc.languageen
dc.publisherWiley-blackwell
dc.publisherMalden
dc.publisherEUA
dc.relationJournal Of Oral Pathology & Medicine
dc.relationJ. Oral Pathol. Med.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectclinicopathological aspects
dc.subjectKi-67
dc.subjectMcm-2
dc.subjectMcm-5
dc.subjectp53
dc.subjectproliferative verrucous leukoplakia
dc.subjectSquamous-cell Carcinoma
dc.subjectOral Leukoplakia
dc.subjectMalignant-transformation
dc.subjectIndian Villagers
dc.subjectPredictive-value
dc.subjectNatural-history
dc.subjectLesions
dc.subjectMarkers
dc.subjectHead
dc.subjectNeck
dc.titleClinicopathological features and immunohistochemical expression of p53, Ki-67, Mcm-2 and Mcm-5 in proliferative verrucous leukoplakia
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución