Pycnogenol (R) protects against ionizing radiation as shown in the intestinal mucosa of rats exposed to X-rays

dc.creatorRamos, FMD
dc.creatorSchonlau, F
dc.creatorNovaes, PD
dc.creatorManzi, FR
dc.creatorBoscolo, FN
dc.creatorde Almeida, SM
dc.date2006
dc.dateAUG
dc.date2014-11-16T17:52:26Z
dc.date2015-11-26T17:26:08Z
dc.date2014-11-16T17:52:26Z
dc.date2015-11-26T17:26:08Z
dc.date.accessioned2018-03-29T00:13:20Z
dc.date.available2018-03-29T00:13:20Z
dc.identifierPhytotherapy Research. John Wiley & Sons Ltd, v. 20, n. 8, n. 676, n. 679, 2006.
dc.identifier0951-418X
dc.identifierWOS:000239857900010
dc.identifier10.1002/ptr.1934
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58496
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/58496
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58496
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1284487
dc.descriptionX-rays and gamma radiation delivered to the abdominal region for cancer treatment encompasses severe damage to the intestinal mucosa, which significantly impairs a patient's quality of life. To a great extent the deleterious effects of x-radiation originate from radiolysis-induced reactive oxygen species. The well-researched powerful antioxidant Pycnogenol (R) was administered orally to rats prior to x-irradiation with 15 Gy. Histological sections of the intestines showed a dramatically better condition of the mucosal layers compared with the irradiated control animals administered water without Pycnogenol (R). Pycnogenol (R) treatment significantly preserved the height and number of villi as well as the glandular layer and a diminished number of congested vases were present. No intestinal alterations were seen in control animals receiving Pycnogenol (R) in the absence of radiation. It is concluded that Pycnogenol (R) provides significant protection from ionizing radiation damage. Copyright (c) 2006 John Wiley & Sons, Ltd.
dc.description20
dc.description8
dc.description676
dc.description679
dc.languageen
dc.publisherJohn Wiley & Sons Ltd
dc.publisherChichester
dc.publisherInglaterra
dc.relationPhytotherapy Research
dc.relationPhytother. Res.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectintestinal mucosa
dc.subjectradiation
dc.subjectionizing
dc.subjectradiation protective agents
dc.subjectPycnogenol (R)
dc.subjectExtract
dc.subjectBark
dc.subjectRadioprotection
dc.subjectAntioxidants
dc.subjectRich
dc.titlePycnogenol (R) protects against ionizing radiation as shown in the intestinal mucosa of rats exposed to X-rays
dc.typeArtículos de revistas


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