ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: Correlation with clinical outcomes

dc.creatorSilva, SD
dc.creatorPerez, DE
dc.creatorAlves, FA
dc.creatorNishimoto, IN
dc.creatorPinto, CAL
dc.creatorKowalski, LP
dc.creatorGraner, E
dc.date2008
dc.dateMAY
dc.date2014-11-16T17:45:26Z
dc.date2015-11-26T17:26:08Z
dc.date2014-11-16T17:45:26Z
dc.date2015-11-26T17:26:08Z
dc.date.accessioned2018-03-29T00:13:19Z
dc.date.available2018-03-29T00:13:19Z
dc.identifierOral Oncology. Elsevier Science Bv, v. 44, n. 5, n. 484, n. 490, 2008.
dc.identifier1368-8375
dc.identifierWOS:000256331800010
dc.identifier10.1016/j.oraloncology.2007.06.008
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65539
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/65539
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65539
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1284484
dc.descriptionThe oncoprotein ErbB2 (HER-2/neu) is a tyrosine kinase cell surface receptor overexpressed in several human malignancies, including oral squamous cell carcinoma (OSCC). ErbB2 was recently shown to regulate the expression of fatty acid synthase (FAS), a multifunctional enzyme complex responsible for the de novo biosynthesis of saturated fatty acids. Here we evaluated the relationship between the immunohistochemical expression of ErbB2, FAS, and Ki-67 with the clinicopathologic characteristics of tongue squamous cell carcinoma (SCC). One hundred and two patients with tongue SCC treated from 1990 to 1995 were studied. Clinical and treatment data were obtained from the medical records and histo pathological features revised. Paraffin-embedded tissues were submitted to standard immunohistochemical reactions for ErbB2, FAS and Ki-67. A strong positive correlation between ErbB2 labeling at the cell membrane and FAS expression was found in the tongue SCC samples (p < 0.0001). The intracytoplasmatic expression of ErbB2 as well as Ki-67 nuclear staining were significantly associated with a high risk of recurrence by predicting both disease free survival (log-rank test, p = 0.0096 and p = 0.0047, respectively) and overall survival (log-rank test, p = 0.0029 and p = 0.0001, respectively). Taken together, our results suggest that the immunolocalization of ErbB2 at the cell surface of malignant oral keratinocytes is linked to FAS expression whereas the intracytoplasmatic ErbB2 or Ki-67 staining predict high risk of recurrence of tongue SCC. (c) 2007 Elsevier Ltd. All rights reserved.
dc.description44
dc.description5
dc.description484
dc.description490
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationOral Oncology
dc.relationOral Oncol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectoral squamous cell
dc.subjectcarcinoma
dc.subjectoral cancer
dc.subjectErbB2
dc.subjectfatty acid synthase
dc.subjectKi-67
dc.subjectprognostic factor
dc.subjectsurvival analysis
dc.subjectPotential Therapeutic Target
dc.subjectBreast-cancer Cells
dc.subjectProstate-cancer
dc.subjectPharmacological Inhibition
dc.subjectOvarian Neoplasms
dc.subjectIncreased Risk
dc.subjectOncogene
dc.subjectHer-2/neu
dc.subjectReceptor
dc.subjectHer2
dc.titleErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: Correlation with clinical outcomes
dc.typeArtículos de revistas


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