dc.creatorEndo, LH
dc.creatorFerreira, D
dc.creatorMontenegro, MCS
dc.creatorPinto, GA
dc.creatorAltemani, A
dc.creatorBortoleto, AE
dc.creatorVassallo, J
dc.date2001
dc.dateAPR 6
dc.date2014-11-16T16:49:26Z
dc.date2015-11-26T17:25:50Z
dc.date2014-11-16T16:49:26Z
dc.date2015-11-26T17:25:50Z
dc.date.accessioned2018-03-29T00:13:02Z
dc.date.available2018-03-29T00:13:02Z
dc.identifierInternational Journal Of Pediatric Otorhinolaryngology. Elsevier Sci Ireland Ltd, v. 58, n. 1, n. 9, n. 15, 2001.
dc.identifier0165-5876
dc.identifierWOS:000167695900002
dc.identifier10.1016/S0165-5876(00)00446-8
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61303
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/61303
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61303
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1284410
dc.descriptionRecurrent tonsillitis has been the subject of much investigation. Events considered to predispose to or cause recurrent tonsillitis (RT) include the misuse of antibiotic therapy in acute bouts, alterations in the microflora, structural changes in crypt epithelium and certain viral infections. Epstein-Barr Virus (EBV) infection usually occurs in early childhood and can persist in palatine tonsil lymphocytes to induce tonsillitis at a later date. We have examined the presence of EBV in palatine tonsils in order to assess the relationship between this virus and recurrent acute tonsillitis. Tonsils were obtained from 85 patients, 2-14 years old (mean 5.6 years old) who underwent tonsils and adenoid (T&A) removal because of recurrent tonsillitis (RT) or T&A hypertrophy (TH). Tissues specimens were processed for non-isotopic in situ hybridization (ISH) using EBER 1/2 oligonucleolides (EBER RNA). The indications for surgery were RT in 42 patients and TH in 43 patients. In 25 out of 85 cases (29.4%) a positive EBER RNA reaction (15 RT and 33 TH) was found. The chi (2)-test showed no statistically significant difference in frequency of positive results between RT and TH group. We conclude that tonsils of children can be colonized by EBV and that the virus may be implicated in RT and TH. (C) 2001 Elsevier Science Ireland Ltd. Ail rights reserved.
dc.description58
dc.description1
dc.description9
dc.description15
dc.languageen
dc.publisherElsevier Sci Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationInternational Journal Of Pediatric Otorhinolaryngology
dc.relationInt. J. Pediatr. Otorhinolaryngol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectEpstein-Barr virus
dc.subjectin situ hybridization
dc.subjectrecurrent tonsillitis
dc.subjecttonsil hypertrophy
dc.subjectAcute Infectious-mononucleosis
dc.subjectIn-situ Hybridization
dc.subjectCells
dc.subjectAssociation
dc.subjectExpression
dc.titleDetection of Epstein-Barr virus in tonsillar tissue of children and the relationship with recurrent tonsillitis
dc.typeArtículos de revistas


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