Assessment of neurosurgical outcome in children prenatally diagnosed with myelomeningocele and development of a protocol for fetal surgery to prevent hydrocephalus

dc.creatorZambelli, H
dc.creatorCarelli, E
dc.creatorHonorato, D
dc.creatorMarba, S
dc.creatorCoelho, G
dc.creatorCarnevalle, A
dc.creatorIscaife, A
dc.creatorda Silva, E
dc.creatorBarini, R
dc.creatorSbragia, L
dc.date2007
dc.dateAPR
dc.date2014-11-16T16:36:58Z
dc.date2015-11-26T17:25:46Z
dc.date2014-11-16T16:36:58Z
dc.date2015-11-26T17:25:46Z
dc.date.accessioned2018-03-29T00:12:59Z
dc.date.available2018-03-29T00:12:59Z
dc.identifierChilds Nervous System. Springer, v. 23, n. 4, n. 421, n. 425, 2007.
dc.identifier0256-7040
dc.identifierWOS:000244750900010
dc.identifier10.1007/s00381-006-0261-x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54994
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/54994
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54994
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1284397
dc.descriptionPrenatal diagnosis of myelomeningocele (MMC) has permitted a better planning for optimum management of the disease. More recently, it has allowed for a possible intrauterine repair of the spinal defect. To describe neurosurgical outcome in children with myelomeningocele and follow-up at a referral center in Fetal Medicine. Patients were characterized for the development of a protocol suitable for fetal surgery, and fetuses who were possible candidates for intrauterine surgery were identified. A retrospective descriptive analysis was performed of 98 cases of fetal myelomeningocele, seen at CAISM-UNICAMP, from January 1994 to December 2002, identifying cases with a possible indication for fetal surgery. Mean gestational age at diagnosis was 29 weeks (17-39); level of lesion was above the sacral region in 92.84%; association with hydrocephalus occurred in 78.57%. During clinical course, 82.5% of patients had neurogenic bladder and 60% had neural and mental deficits. Potential intrauterine repair rate was 11.57%, using criteria from the protocol developed in our service. Myelomeningocele is associated with severe and frequent sequelae. In virtually 12% of our cases, fetal surgery could have been offered as a therapeutic option.
dc.description23
dc.description4
dc.description421
dc.description425
dc.languageen
dc.publisherSpringer
dc.publisherNew York
dc.publisherEUA
dc.relationChilds Nervous System
dc.relationChilds Nerv. Syst.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectprenatal diagnosis
dc.subjectmyelomeningocele
dc.subjecthydrocephalus
dc.subjectfetal surgery
dc.subjectIn-utero
dc.subjectSpinal-cord
dc.subjectMeningomyelocele
dc.subjectManagement
dc.subjectRepair
dc.subjectBifida
dc.subjectModel
dc.titleAssessment of neurosurgical outcome in children prenatally diagnosed with myelomeningocele and development of a protocol for fetal surgery to prevent hydrocephalus
dc.typeArtículos de revistas


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