Biology of the repair of central nervous system demyelinated lesions

dc.creatorPeireira, LAV
dc.creatorCruzHofling, MA
dc.creatorDertkigil, MSJ
dc.creatorGraca, DL
dc.date1996
dc.dateJUN
dc.date2014-12-16T11:36:33Z
dc.date2015-11-26T17:25:33Z
dc.date2014-12-16T11:36:33Z
dc.date2015-11-26T17:25:33Z
dc.date.accessioned2018-03-29T00:12:46Z
dc.date.available2018-03-29T00:12:46Z
dc.identifierArquivos De Neuro-psiquiatria. Assoc Arquivos De Neuro- Psiquiatria, v. 54, n. 2, n. 331, n. 334, 1996.
dc.identifier0004-282X
dc.identifierWOS:A1996UM75400026
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55616
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/55616
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55616
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1284341
dc.descriptionThe integrity of myelin sheaths is maintained by oligodendrocytes and Schwann cells respectively in the central nervous system (CNS) and in the peripheral nervous system. The process of demyelination consisting of the withdrawal of myelin sheaths from their axons is a characteristic feature of multiple sclerosis, the most common human demyelinating disease. Many experimental models have been designed to study the biology of demyelination and remyelination (repair of the lost myelin) in the CNS, due to the difficulties in studying human material. In the ethidium bromide (an intercalating gliotoxic drug) model of demyelination, CNS remyelination may be carried out by surviving oligodendrocytes and/or by cells differentiated from the primitive cell lines or either by Schwann cells that invade the CNS. However, some factors such as the age of the experimental animals, intensity and time of exposure to the intercalating chemical and the topography of the lesions have marked influence on the repair of the tissue.
dc.description54
dc.description2
dc.description331
dc.description334
dc.languageen
dc.publisherAssoc Arquivos De Neuro- Psiquiatria
dc.publisherSao Paulo Sp
dc.publisherBrasil
dc.relationArquivos De Neuro-psiquiatria
dc.relationArq. Neuro-Psiquiatr.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjecttoxic demyelination
dc.subjectremyelination
dc.subjectcentral nervous system
dc.subjectperipheral nervous system
dc.subjectRat Optic-nerve
dc.subjectMultiple-sclerosis
dc.subjectSchwann-cells
dc.subjectRemyelination
dc.subjectInjection
dc.subjectAxons
dc.subjectBrain
dc.subjectMice
dc.titleBiology of the repair of central nervous system demyelinated lesions
dc.typeArtículos de revistas


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