Desorption sonic spray ionization for (high) voltage-free ambient mass spectrometry

dc.creatorHaddad, R
dc.creatorSparrapan, R
dc.creatorEberlin, MN
dc.date2006
dc.date2014-11-16T15:35:13Z
dc.date2015-11-26T17:25:32Z
dc.date2014-11-16T15:35:13Z
dc.date2015-11-26T17:25:32Z
dc.date.accessioned2018-03-29T00:12:45Z
dc.date.available2018-03-29T00:12:45Z
dc.identifierRapid Communications In Mass Spectrometry. John Wiley & Sons Ltd, v. 20, n. 19, n. 2901, n. 2905, 2006.
dc.identifier0951-4198
dc.identifierWOS:000241040400015
dc.identifier10.1002/rcm.2680
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61272
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/61272
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61272
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1284336
dc.descriptionSonic spray ionization is shown to create a supersonic cloud of charged droplets able to promote efficient desorption and ionization of drugs directly from the surfaces of commercial drug tablets at ambient conditions. Compared with desorption electrospray ionization (DESI), desorption sonic spray ionization (DeSSI) is advantageous since it uses neither heating nor high voltages at the spray capillary. DeSSI therefore provides a more friendly environment in which to perform ambient mass spectrometry (MS). DeSSI-MS is herein evaluated for the analysis of drug tablets, and found to be, in general, as sensitive as DESI-MS. The (high) voltage-free DeSSI method provides, however, cleaner mass spectra with less abundant solvent cluster ions and with enough abundant analyte signal for tandem mass spectrometry (MS/MS). These features may therefore facilitate the DeSSI-MS detection of low molar mass components or impurities, or both. The higher-velocity supersonic DeSSI spray also facilitates matrix penetration thus providing more homogenous sampling and longer lasting ion signals. Copyright (c) 2006 John Wiley & Sons, Ltd.
dc.description20
dc.description19
dc.description2901
dc.description2905
dc.languageen
dc.publisherJohn Wiley & Sons Ltd
dc.publisherChichester
dc.publisherInglaterra
dc.relationRapid Communications In Mass Spectrometry
dc.relationRapid Commun. Mass Spectrom.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectElectrospray-ionization
dc.subjectAtmospheric-pressure
dc.subjectSamples
dc.subjectIon
dc.titleDesorption sonic spray ionization for (high) voltage-free ambient mass spectrometry
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución