FOOTSHOCK STRESS-INDUCED SUPERSENSITIVITY TO ISOPRENALINE IN THE ISOLATED PACEMAKER OF THE RAT - EFFECTS OF THE COMPOUNDS RU-38486 AND RU-28362

dc.creatorNOURANI, FRR
dc.creatorSPADARI, RC
dc.creatorDEMORAES, S
dc.date1992
dc.dateJUL
dc.date2014-12-16T11:36:32Z
dc.date2015-11-26T17:25:23Z
dc.date2014-12-16T11:36:32Z
dc.date2015-11-26T17:25:23Z
dc.date.accessioned2018-03-29T00:12:38Z
dc.date.available2018-03-29T00:12:38Z
dc.identifierGeneral Pharmacology-the Vascular System. Elsevier Science Inc, v. 23, n. 4, n. 787, n. 791, 1992.
dc.identifier0306-3623
dc.identifierWOS:A1992JF22300037
dc.identifier10.1016/0306-3623(92)90167-I
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/67013
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/67013
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/67013
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1284307
dc.description1. Three daily sessions of inescapable footshock stress of 30 min duration each increased the sensitivity of the isolated pacemaker of the rat to the chronotropic effect of isoprenaline. 2. The effect of inescapable footshock stress on the sensitivity of the isolated rat pacemaker to the chronotropic effect of isoprenaline was prevented by the daily administration of the compound RU-38486, a potent antiglucocorticoid which blocks the cytosolic receptor for corticosterone. 3. The administration of the compound RU-28362. a potent agonist of the cytosolic receptor for corticosterone, during 3 days to rats which were not submitted to footshock stress induces supersensitivity to the chronotropic effect of isoprenaline. 4. It is concluded that corticosterone plays an important role in the qualitative control of the rat pacemaker beta-adrenoceptor population during adaptation to repeated footshock stress.
dc.description23
dc.description4
dc.description787
dc.description791
dc.languageen
dc.publisherElsevier Science Inc
dc.publisherNew York
dc.publisherEUA
dc.relationGeneral Pharmacology-the Vascular System
dc.relationGen. Pharmacol.-The Vasc. Syst.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectBeta-adrenergic Receptors
dc.subjectRepeated Restraint Stress
dc.subjectCold-exposed Rats
dc.subjectBrain Slices
dc.subjectCyclic-amp
dc.subjectAtria
dc.subjectAdrenoceptors
dc.subjectNorepinephrine
dc.subjectSubsensitivity
dc.subjectHypothesis
dc.titleFOOTSHOCK STRESS-INDUCED SUPERSENSITIVITY TO ISOPRENALINE IN THE ISOLATED PACEMAKER OF THE RAT - EFFECTS OF THE COMPOUNDS RU-38486 AND RU-28362
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución