Protective modulation of carotid atherosclerosis in hyperalphalipoproteinemic individuals

dc.creatorSantiago, FD
dc.creatorNakamura, RT
dc.creatorKaplan, D
dc.creatorde Faria, EC
dc.date2010
dc.dateJAN
dc.date2014-11-16T13:03:52Z
dc.date2015-11-26T17:24:57Z
dc.date2014-11-16T13:03:52Z
dc.date2015-11-26T17:24:57Z
dc.date.accessioned2018-03-29T00:12:14Z
dc.date.available2018-03-29T00:12:14Z
dc.identifierInternational Journal Of Cardiovascular Imaging. Springer, v. 26, n. 1, n. 27, n. 34, 2010.
dc.identifier1569-5794
dc.identifierWOS:000272870100004
dc.identifier10.1007/s10554-009-9498-2
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58317
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/58317
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58317
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1284209
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionTo determine whether hyperalphalipoproteinemia modifies carotid intima-media thickness (cIMT) and/or influences the relationship of clinical and biochemical parameters with cIMT. This study was conducted on 169 asymptomatic individuals, classified as hyperalphalipoproteinemic (Hyper-A) (Hyper-A, n = 71, HDL-C a parts per thousand yen68 mg/dL) and controls (CTL) (CTL, n = 98, HDL-C > 32 and < 68 mg/dL). Enzymatic, nephelometric and ultracentrifugation methods were used for biochemical determinations. Hepatic lipase (HL), lipoprotein lipase (LPL), cholesteryl ester transfer protein (CETP) and phospholipids transfer protein (PLTP) activities were measured by radiometric exogenous methods. The prevalence of dyslipidemia, hypertension, smoking, sedentariness, postmenopausal women, coronary artery disease (CAD) and familial history of CAD were determined. High resolution beta-mode carotid ultrassonography was performed. The Hyper-A group was older and had higher frequencies of hypercholesterolemia (40%), hypertension (31%), sedentariness (37%) and postmenopausal women (1%). In Hyper-A individuals, the mean cIMT after adjustment for age and gender was similar between the groups (0.85 +/- A 0.24 mm Hyper-A versus 0.69 +/- A 0.17 mm CTL). In multivariate models, age was a significant predictor of cIMT in Hyper-A (R (2) = 0.04, p a parts per thousand currency sign 0.001), independently of other clinical or biochemical factors. In contrast to CTL, where age (R (2) = 0.63 p a parts per thousand currency sign 0.001), male sex (R (2) = 0.03, p a parts per thousand currency sign 0.001), blood pressure (R (2) = 0.006, p a parts per thousand currency sign 0.001) and HDL-C (R (2) = 0.02, p < 0.022) accounted for the cIMT variations. Despite an increased prevalence of cardiovascular risk factors in Hyper-A and resistance of carotid thickness to modulation by metabolic and anthropometric factors (except age), the similarity in cIMT between Hyper-A and healthy individuals emphasizes the atheroprotective effects of HDL.
dc.description26
dc.description1
dc.description27
dc.description34
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherSpringer
dc.publisherDordrecht
dc.publisherHolanda
dc.relationInternational Journal Of Cardiovascular Imaging
dc.relationInt. J. Cardiovasc. Imaging
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectCarotid atherosclerosis modulation
dc.subjectHyperalphalipoproteinemia
dc.subjectCholesteryl-ester Transfer
dc.subjectHigh-density-lipoprotein
dc.subjectIntima-media Thickness
dc.subjectTransfer Protein Gene
dc.subjectArterial-wall Thickness
dc.subjectCardiovascular-disease
dc.subjectAntioxidative Activity
dc.subjectSurrogate Marker
dc.subjectHdl-cholesterol
dc.subjectLipase Activity
dc.titleProtective modulation of carotid atherosclerosis in hyperalphalipoproteinemic individuals
dc.typeArtículos de revistas


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