The influence of age, sex, race, refractive error and optic disc parameters on the sensitivity and specificity of scanning laser polarimetry

dc.creatorCosta, VP
dc.creatorLauande-Pimentel, R
dc.creatorFonseca, RA
dc.creatorMagacho, L
dc.date2004
dc.dateAUG
dc.date2014-11-16T11:01:22Z
dc.date2015-11-26T17:24:35Z
dc.date2014-11-16T11:01:22Z
dc.date2015-11-26T17:24:35Z
dc.date.accessioned2018-03-29T00:11:52Z
dc.date.available2018-03-29T00:11:52Z
dc.identifierActa Ophthalmologica Scandinavica. Blackwell Munksgaard, v. 82, n. 4, n. 419, n. 425, 2004.
dc.identifier1395-3907
dc.identifierWOS:000223473100009
dc.identifier10.1111/j.1600-0420.2004.00294.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73461
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/73461
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73461
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1284115
dc.descriptionPurpose: To evaluate the influence of age, sex, race, refractive error and optic disc topography on the sensitivity and specificity of scanning laser polarimetry (SLP) in the diagnosis of glaucoma. Methods: A total of 88 normal individuals and 95 glaucoma patients were included in this study. Glaucoma was defined on the basis of both optic nerve damage and visual field defects. Scanning laser polarimetry, optic disc topography, automated perimetry and refractometry were performed in all subjects. The sensitivity and specificity of SLP were assessed applying a previously calculated cut-off to a previously described linear discriminant function (LDF). Results: The sensitivity and specificity of SLP in the study population were 82% and 83%, respectively. Sensitivity and specificity were not affected by age, sex, race, average disc diameter or disc area. The sensitivity of SLP tended to be higher in myopes (93%) than in emmetropes (80%) and hyperopes (71%) (p = 0.08). Sensitivities were higher in individuals with cup areas > 0.96 mm(2) (89%), rim areas less than or equal to 1.36 mm(2) (92%), and cup area/disc area ratios > 0.45 (89%) (p < 0.05). Stepwise logistic regression analysis indicated that the presence of a cup area > 0.96 mm(2) and a rim area < 1.36 mm(2) significantly increased the sensitivity of the LDF, whereas a cup area/disc area ratio &LE;0.45 significantly increased the specificity of the LDF. Conclusion: The sensitivity and specificity of SLP may be influenced by refractive error and optic disc parameters that are affected by glaucomatous damage (cup area, rim area and cup area/disc area ratio). These parameters must be considered in studies evaluating the sensitivity and specificity of optic nerve/retinal nerve fibre layer imaging technologies.
dc.description82
dc.description4
dc.description419
dc.description425
dc.languageen
dc.publisherBlackwell Munksgaard
dc.publisherCopenhagen
dc.publisherDinamarca
dc.relationActa Ophthalmologica Scandinavica
dc.relationActa Ophthalmol. Scand.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectglaucoma
dc.subjectoptic disc
dc.subjectnerve fibre layer
dc.subjectscanning laser polarimetry
dc.subjectsensitivity specificity
dc.subjectNerve-fiber Layer
dc.subjectOcular Hypertension
dc.subjectGlaucomatous Eyes
dc.subjectThickness
dc.subjectDiscrimination
dc.subjectDamage
dc.subjectField
dc.subjectSize
dc.titleThe influence of age, sex, race, refractive error and optic disc parameters on the sensitivity and specificity of scanning laser polarimetry
dc.typeArtículos de revistas


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