Acute effects of pharmacotherapies in blood pressure in normotensive moderate smokers

dc.creatorMartins, LC
dc.creatorFerreira-Melo, SE
dc.creatorSabha, M
dc.creatorCoelho, OR
dc.creatorCarlosyugar-Toledo, J
dc.creatorQuinaglia, T
dc.creatorMoreira, MM
dc.creatorCoca, A
dc.creatorMoreno, H
dc.date2009
dc.date2014-11-16T09:26:24Z
dc.date2015-11-26T17:24:17Z
dc.date2014-11-16T09:26:24Z
dc.date2015-11-26T17:24:17Z
dc.date.accessioned2018-03-29T00:11:35Z
dc.date.available2018-03-29T00:11:35Z
dc.identifierBlood Pressure. Taylor & Francis As, v. 18, n. 5, n. 255, n. 260, 2009.
dc.identifier0803-7051
dc.identifierWOS:000271186400004
dc.identifier10.1080/08037050903289606
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54196
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/54196
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54196
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1284040
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThis study was designed to evaluate the changes in arterial blood pressure (BP) and heart rate (HR) in moderate smokers during smoking abstinence after 7 days of treatment with bupropion alone, transdermal nicotine or bupropion combined with transdermal nicotine. Twenty-four healthy moderate smokers (12 female/12 male; 40 +/- 7 years) were evaluated randomly on five occasions and their systolic, diastolic, mean arterial blood pressure (MAP) and HR were measured by a Finapres device for 10 h, immediately after smoking interruption. All of the 24 smokers participated on five protocols during 7 days: control group (C)-no drugs; placebo group (PL); bupropion group (BUP) 150-300 mg; transdermal nicotine group (TN) -21 mg; and BUP + TN-nicotine patch. Concomitantly, the subjects were evaluated by ABPM (ambulatory BP monitoring). All of BP parameters monitored shown significant statistical differences in the BUP, TN and BUP + TN groups compared with the controls (p < 0.05), when measured by Finapres. The HR remained unaltered in all of the groups. No significant differences were seen in the BP or HR during the 24-h ABPM. These findings indicate that in moderate smokers, bupropion, transdermal nicotine or bupropion associated with transdermal nicotine caused an elevation in the BP after acute smoking interruption.
dc.description18
dc.description5
dc.description255
dc.description260
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAEPEX-UNICAMP (Brasil)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherTaylor & Francis As
dc.publisherOslo
dc.publisherNoruega
dc.relationBlood Pressure
dc.relationBlood Pressure
dc.rightsfechado
dc.rightshttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.sourceWeb of Science
dc.subjectEndothelium
dc.subjecthypertension
dc.subjectsmoking cessation
dc.subjecttobacco
dc.subjectvascular function
dc.subjectSmoking-cessation
dc.subjectTransdermal Nicotine
dc.subjectCigarette-smoking
dc.subjectEndothelial Dysfunction
dc.subjectTobacco Use
dc.subjectBupropion
dc.subjectHumans
dc.subjectHypertension
dc.subjectRelease
dc.subjectAbsorption
dc.titleAcute effects of pharmacotherapies in blood pressure in normotensive moderate smokers
dc.typeArtículos de revistas


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