Brasil | Artículos de revistas
dc.creatorBruni-Cardoso, A
dc.creatorLynch, CC
dc.creatorRosa-Ribeiro, R
dc.creatorMatrisian, LM
dc.creatorCarvalho, HF
dc.date2010
dc.dateSEP
dc.date2014-11-16T07:57:26Z
dc.date2015-11-26T17:23:57Z
dc.date2014-11-16T07:57:26Z
dc.date2015-11-26T17:23:57Z
dc.date.accessioned2018-03-29T00:11:15Z
dc.date.available2018-03-29T00:11:15Z
dc.identifierDevelopmental Dynamics. Wiley-liss, v. 239, n. 9, n. 2386, n. 2392, 2010.
dc.identifier1058-8388
dc.identifierWOS:000281724800006
dc.identifier10.1002/dvdy.22382
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57162
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57162
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57162
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283956
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionEpithelial growth, branching, and canalization are important morphogenetic events of the rodent ventral prostate (VP) that take place during the first postnatal week. In this study, we evaluated the effect of knocking out MMP-2 (MMP-2(-/-)), by examining developmental and structural aspects of the VP in MMP-2(-/-) mice. Neonate (day 6) MMP-2(-/-) mice showed fewer epithelial tips, a lower epithelial cell proliferation rate, and also reticulin fiber accumulation. The VP of adult MMP-2-/- mice showed lower relative weight, smaller epithelial and smooth-muscle cell volume, and a larger amount of thicker reticulin fibers. No differences in cell proliferation or apoptotic index were noted between adult MMP-2(-/-) and wild-type mice. MMP-9 was found in the adult MMP-2(-/-), but not in the wild-type. In conclusion, MMP-2 function is essential for the epithelial morphogenesis of the mouse VP, and expression of MMP-9 is not sufficient for acquisition of the normal adult histology. Developmental Dynamics 239:2386-2392, 2010. (c) 2010 Wiley-Liss, Inc.
dc.description239
dc.description9
dc.description2386
dc.description2392
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionState of Sao Paulo Research Funding Agency
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [07/07564-6]
dc.languageen
dc.publisherWiley-liss
dc.publisherHoboken
dc.publisherEUA
dc.relationDevelopmental Dynamics
dc.relationDev. Dyn.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectprostate development
dc.subjectMMP-2, MMP-9, reticulin fibers
dc.subjectventral prostate
dc.subjectGland Branching Morphogenesis
dc.subjectMatrix Metalloproteinases
dc.subjectPostnatal-development
dc.subjectIn-vitro
dc.subjectRat
dc.subjectExpression
dc.subjectCancer
dc.subjectMice
dc.subjectLung
dc.subjectCastration
dc.titleMMP-2 Contributes to the Development of the Mouse Ventral Prostate by Impacting Epithelial Growth and Morphogenesis
dc.typeArtículos de revistas


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