Coordinated and circumlocutory semantic naming errors are related to anterolateral temporal lobes in mild AD, amnestic mild cognitive impairment, and normal aging

dc.creatorBalthazar, MLF
dc.creatorYasuda, CL
dc.creatorPereira, FRS
dc.creatorBergo, FPG
dc.creatorCendes, F
dc.creatorDamasceno, BP
dc.date2010
dc.dateNOV
dc.date2014-11-16T07:34:31Z
dc.date2015-11-26T17:23:54Z
dc.date2014-11-16T07:34:31Z
dc.date2015-11-26T17:23:54Z
dc.date.accessioned2018-03-29T00:11:12Z
dc.date.available2018-03-29T00:11:12Z
dc.identifierJournal Of The International Neuropsychological Society. Cambridge Univ Press, v. 16, n. 6, n. 1099, n. 1107, 2010.
dc.identifier1355-6177
dc.identifierWOS:000285023200017
dc.identifier10.1017/S1355617710000998
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57185
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57185
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57185
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283945
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionNaming difficulties are characteristic of Alzheimer s disease (AD) and to a lesser extent, of amnestic mild cognitive impairment (aMCI) patients The association of naming impairment with anterior temporal lobe (ATL) atrophy in Semantic Dementia (SD) could be a tip of the Iceberg effect in which case the atrophy is a marker of more generalized temporal lobe pathology Alternatively, it could reflect the existence of a functional gradient within the temporal lobes wherein more anterior regions provide the basis for greater specificity of representation We tested these two hypotheses in a study of 15 subjects with mild AD 17 with aMCI and 16 aged control subjects and showed that coordinate and circumlocutory semantic error production on the Boston Naming Test was weakly correlated with ATL gray matter density as determined by voxel based morphometry Additionally we investigated whether these errors were benefited by phonemic cues, and similarly to SD, our AD patients had small improvement Because there is minimal gradient of temporal lobe atrophy in AD or MCI and therefore, no basis for a tip of the iceberg effect these findings support the theory of a modest functional gradient in the temporal lobes with the ATLs being Involved in the naming of more specific objects (JINS 2010 16, 1099-1107)
dc.descriptiono TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.
dc.description16
dc.description6
dc.description1099
dc.description1107
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2009/02179-2]
dc.languageen
dc.publisherCambridge Univ Press
dc.publisherNew York
dc.publisherEUA
dc.relationJournal Of The International Neuropsychological Society
dc.relationJ. Int. Neuropsychol. Soc.
dc.rightsembargo
dc.rightshttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.sourceWeb of Science
dc.subjectSemantic memory
dc.subjectTemporal lobe
dc.subjectNaming
dc.subjectCueing
dc.subjectVoxel-based morphometry
dc.subjectMild cognitive impairment
dc.subjectVoxel-based Morphometry
dc.subjectMini-mental-state
dc.subjectAlzheimers-disease
dc.subjectFrontotemporal Dementia
dc.subjectMemory Loss
dc.subjectKnowledge
dc.subjectDeficits
dc.subjectDepression
dc.subjectAphasia
dc.subjectAtrophy
dc.titleCoordinated and circumlocutory semantic naming errors are related to anterolateral temporal lobes in mild AD, amnestic mild cognitive impairment, and normal aging
dc.typeArtículos de revistas


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