Euphorbia tirucalli L. modulates myelopoiesis and enhances the resistance of tumour-bearing mice

dc.creatorValadares, MC
dc.creatorCarrucha, SG
dc.creatorAccorsi, W
dc.creatorQueiroz, MLS
dc.date2006
dc.dateFEB
dc.date2014-11-16T07:29:06Z
dc.date2015-11-26T17:23:54Z
dc.date2014-11-16T07:29:06Z
dc.date2015-11-26T17:23:54Z
dc.date.accessioned2018-03-29T00:11:12Z
dc.date.available2018-03-29T00:11:12Z
dc.identifierInternational Immunopharmacology. Elsevier Science Bv, v. 6, n. 2, n. 294, n. 299, 2006.
dc.identifier1567-5769
dc.identifierWOS:000234884400020
dc.identifier10.1016/j.intimp.2005.07.013
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65711
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/65711
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65711
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283942
dc.descriptionMyelosuppression concomitant with increased numbers of spleen CFU-GM was observed in tumour-bearing mice. Treatment of these animals with Euphorbia tirucalli L. (ET) (125, 250 and 500 mg/kg) stimulated marrow myelopoiesis and reduced spleen colony formation, with no differences observed between the effects of the three doses. The changes produced by the tumour in total and differential marrow cell counts were restored by the treatment with ET. Prostaglandin E2 (PGE2) levels, which were dramatically increased in tumour bearers, was also abrogated by the treatment with the plant extract. Euphorbia tirucalli L. significantly enhanced survival and concurrently reduced tumour growth in the peritoneal cavity. We propose that the modulatory effect of Euphorbia tirucalli L on myelopoietic response and on the levels of PGE2 may be related to its antitumour activity as a possible mechanism for the regulation of granulocyte and macrophage production and expression of functional activities. (c) 2005 Elsevier B.V. All rights reserved.
dc.description6
dc.description2
dc.description294
dc.description299
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationInternational Immunopharmacology
dc.relationInt. Immunopharmacol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectEuphorbia tirucalli L.
dc.subjectehrlich ascites tumour
dc.subjectmyelopoiesis
dc.subjectantitumoural
dc.subjectEhrlich Tumor
dc.subjectBone-marrow
dc.subjectHematopoietic Response
dc.subjectActive Principles
dc.subjectDiterpene Esters
dc.subjectCells
dc.subjectDifferentiation
dc.subjectIrritant
dc.subjectExtract
dc.subjectNivulia
dc.titleEuphorbia tirucalli L. modulates myelopoiesis and enhances the resistance of tumour-bearing mice
dc.typeArtículos de revistas


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