Mitochondrial oxidative stress after global brain ischemia in rats

dc.creatorFriberg, H
dc.creatorWieloch, T
dc.creatorCastilho, RF
dc.date2002
dc.dateDEC 13
dc.date2014-11-16T05:46:29Z
dc.date2015-11-26T17:23:34Z
dc.date2014-11-16T05:46:29Z
dc.date2015-11-26T17:23:34Z
dc.date.accessioned2018-03-29T00:10:53Z
dc.date.available2018-03-29T00:10:53Z
dc.identifierNeuroscience Letters. Elsevier Ireland Ltd, v. 334, n. 2, n. 111, n. 114, 2002.
dc.identifier0304-3940
dc.identifierWOS:000179523900011
dc.identifier10.1016/S0304-3940(02)01116-3
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57123
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57123
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57123
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283858
dc.descriptionVulnerable neurons in the hippocampus die 2-3 days after transient global brain ischemia. In the present study, rat brain mitochondria were isolated at different time points (4 h, 24 h and 48 h) after transient global ischemia. Detection of mitochondrially-generated reactive oxygen species, measured through dichlorodihydrofluorescein oxidation, was increased up to 40% relative to control in hippocampal mitochondria at 4 h and 48 h of reperfusion. Ischemia-stimulated oxidative stress was observed with mitochondria oxidizing substrates linked to nicotinamide adenine dinucleotide or flavin adenine dinucleotide, but not in the presence of the respiratory chain inhibitor antimycin A. A slightly decreased Ca2+ uptake capacity was observed in hippocampal mitochondria during reperfusion. We conclude that transient brain ischemia induces oxidative stress in hippocampal mitochondria. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
dc.description334
dc.description2
dc.description111
dc.description114
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationNeuroscience Letters
dc.relationNeurosci. Lett.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectbrain
dc.subjectcalcium
dc.subjectcyclosporin A
dc.subjectfree radicals
dc.subjectischemia
dc.subjectmitochondria
dc.subjectpermeability transition
dc.subjectTerm Forebrain Ischemia
dc.subjectCerebral-ischemia
dc.subjectPermeability Transition
dc.subjectRecirculation
dc.subjectReperfusion
dc.subjectAntioxidant
dc.subjectOcclusion
dc.subjectDamage
dc.subjectModel
dc.titleMitochondrial oxidative stress after global brain ischemia in rats
dc.typeArtículos de revistas


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