Acetylcholine receptors and neuronal nitric oxide synthase distribution at the neuromuscular junction of regenerated muscle fibers

dc.creatorMinatel, E
dc.creatorNeto, HS
dc.creatorMarques, MJ
dc.date2001
dc.dateMAR
dc.date2014-11-16T04:13:16Z
dc.date2015-11-26T17:23:15Z
dc.date2014-11-16T04:13:16Z
dc.date2015-11-26T17:23:15Z
dc.date.accessioned2018-03-29T00:10:35Z
dc.date.available2018-03-29T00:10:35Z
dc.identifierMuscle & Nerve. John Wiley & Sons Inc, v. 24, n. 3, n. 410, n. 416, 2001.
dc.identifier0148-639X
dc.identifierWOS:000167117100015
dc.identifier10.1002/1097-4598(200103)24:3<410
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54098
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/54098
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54098
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283785
dc.descriptionWe investigated whether the changes in acetylcholine receptor (AChR) distribution and neuronal nitric oxide synthase (nNOS) expression reported for the skeletal muscle of mdx mice were a consequence of muscle fiber regeneration rather than of the absence of dystrophin. Degenerative-regenerative changes in muscle fibers of the sternomastoid muscle of normal mice were induced by injecting lidocaine hydrochloride. Twenty-one days later, AChRs were labeled with alpha-bungarotoxin and nNOS with anti-nNOS antibody, and observed under a confocal microscope. AChRs were distributed in continuous branches in normal fibers. Regenerated fibers showed disruption of AChRs distribution similar to that seen in muscle of mdx mice. This suggests that changes in AChRs distribution seen in mdx mice were probably a consequence of muscle fiber degeneration and regeneration, rather than a symptom of dystrophin deficiency. Conversely, there were no changes in nNOS distribution and expression in normal regenerated fibers, suggesting that the decrease in nNOS expression reported for mdx mice might be attributed to the absence of dystrophin. (C) 2001 John Wiley & Sons, Inc.
dc.description24
dc.description3
dc.description410
dc.description416
dc.languageen
dc.publisherJohn Wiley & Sons Inc
dc.publisherNew York
dc.publisherEUA
dc.relationMuscle & Nerve
dc.relationMuscle Nerve
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectacetylcholine receptors
dc.subjectconfocal microscopy
dc.subjectmdx mice
dc.subjectneuromuscular junction
dc.subjectneuronal nitric oxide synthase
dc.subjectregenerated muscle fibers
dc.subjectDuchenne Muscular-dystrophy
dc.subjectSkeletal-muscle
dc.subjectMdx Mouse
dc.subjectSarcolemma
dc.subjectProtein
dc.subjectGlycoprotein
dc.subjectAssociation
dc.subjectDeficient
dc.subjectComponent
dc.subjectMarcaine
dc.titleAcetylcholine receptors and neuronal nitric oxide synthase distribution at the neuromuscular junction of regenerated muscle fibers
dc.typeArtículos de revistas


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