Dynamic changes in white and gray matter volume are associated with outcome of surgical treatment in temporal lobe epilepsy

dc.creatorYasuda, CL
dc.creatorValise, C
dc.creatorSaude, AV
dc.creatorPereira, AR
dc.creatorPereira, FR
dc.creatorCosta, ALF
dc.creatorMorita, ME
dc.creatorBetting, LE
dc.creatorCastellano, G
dc.creatorGuerreiro, CAM
dc.creatorTedeschi, H
dc.creatorde Oliveira, E
dc.creatorCendes, F
dc.date2010
dc.date36892
dc.date2014-11-16T02:32:18Z
dc.date2015-11-26T17:22:43Z
dc.date2014-11-16T02:32:18Z
dc.date2015-11-26T17:22:43Z
dc.date.accessioned2018-03-29T00:10:08Z
dc.date.available2018-03-29T00:10:08Z
dc.identifierNeuroimage. Academic Press Inc Elsevier Science, v. 49, n. 1, n. 71, n. 79, 2010.
dc.identifier1053-8119
dc.identifierWOS:000272031700008
dc.identifier10.1016/j.neuroimage.2009.08.014
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63566
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/63566
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63566
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283666
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground: The reasons for surgical failure in 30% of patients with unilateral mesial temporal lobe epilepsy (MTLE) are still unclear. We investigated if different outcomes could be associated to different patterns of subtle gray matter atrophy (GMA) and white matter atrophy (WMA), and searched for postoperative magnetic resonance imaging (MRI) changes. Methods: We studied 69 controls and 67 operated patients with refractory unilateral MTLE. Patients were grouped as seizure-free (SF) group (34 patients Engel's IA), worthwhile improvement group (23 patients, Engel's IB-IIA) and failure group (10 patients Engel's IIB-IV). We created a voxel-based morphometry/MATLAB code to mask the surgical lacuna, and performed t-test and paired t-test to evaluate preoperative and postoperative MRI scans. Results: Failure group showed a widespread pattern of preoperative GMA. On SF and improvement groups we identified a more restricted pattern of GMA. The three groups presented a widespread, bilateral pattern of WMA. In contrast, postoperative analyses showed bilateral hemispheric recovery (a relative increase of WM concentration) on SF and improvement groups, but few changes on failure group. We also identified areas with relative postoperative increase of GM on both SF and improvement groups, more widespread on SF group. Conclusion: Areas of subtle GMA may be related to poorer surgical outcome. In addition, we demonstrated a postoperative relative increase of WM and GM concentration associated with seizure control. These changes may represent neuroplasticity related to improvement of brain function after seizure control. Further studies with a multimodal approach may help to predict surgical outcome and improve selection of patients for surgical treatment of MTLE. (c) 2009 Elsevier Inc. All rights reserved.
dc.description49
dc.description1
dc.description71
dc.description79
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [05/59258-0, 07/01676-7, 05/56578-4]
dc.languageen
dc.publisherAcademic Press Inc Elsevier Science
dc.publisherSan Diego
dc.publisherEUA
dc.relationNeuroimage
dc.relationNeuroimage
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectTemporal lobe epilepsy
dc.subjectSeizures
dc.subjectSurgery
dc.subjectMagnetic resonance imaging
dc.subjectVoxel-based morphometry
dc.subjectStatistical parametric mapping
dc.subjectWhite matter damage
dc.subjectVoxel-based Morphometry
dc.subjectSpatial Normalization
dc.subjectHippocampal Sclerosis
dc.subjectBrain
dc.subjectSurgery
dc.subjectAtrophy
dc.subjectSeizures
dc.subjectAbnormalities
dc.subjectLobectomy
dc.subjectAmygdalohippocampectomy
dc.titleDynamic changes in white and gray matter volume are associated with outcome of surgical treatment in temporal lobe epilepsy
dc.typeArtículos de revistas


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