Anaemia in patients with cancer: role of inflammatory activity on iron metabolism and severity of anaemia

dc.creatorJacober, MLV
dc.creatorMamoni, RL
dc.creatorLima, CSP
dc.creatordos Anjos, BL
dc.creatorGrotto, HZW
dc.date2007
dc.date2014-11-16T00:06:18Z
dc.date2015-11-26T17:22:29Z
dc.date2014-11-16T00:06:18Z
dc.date2015-11-26T17:22:29Z
dc.date.accessioned2018-03-29T00:09:56Z
dc.date.available2018-03-29T00:09:56Z
dc.identifierMedical Oncology. Humana Press Inc, v. 24, n. 3, n. 323, n. 329, 2007.
dc.identifier1357-0560
dc.identifierWOS:000249339900009
dc.identifier10.1007/s12032-007-0009-9
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54509
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/54509
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54509
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283615
dc.descriptionHepcidin has been proposed as an important factor in the pathogenesis of the anaemia of chronic disease (ACD). The aim of this study was to assess the relationship between anaemia and inflammatory activity in patients with solid tumours. Patients were classified as having iron deficiency anaernia (IDA) (hypoferremia and hypoferretinemia), ACD (hypoferremia, normal or increased serum ferritin) and anaemia related to cancer (ARC) (no abnormalities in iron status). Serum pro-hepcidin, IL-6, C-reactive protein (CRP) and iron status parameters were measured using commercial kits. CRP and IL-6 levels were significantly higher in patients with ACD when compared to IDA, ARC and non anaemic patients (P < 0.005). Serum pro-hepcidin levels were not different among all studied groups (P = 0.138). A negative correlation was observed between haemoglobin and serum ferritin, CRP and IL-6 levels only in group of ACD. Serum pro-hepcidin concentrations were not correlated with degree of anaemia or iron metabolism parameters. According to our results the inflammatory activity represented by high levels of IL-6 and CRP are involved in the pathogenesis of ACD, probably due to the action of inflammation on iron metabolism, but not in ARC. It was not possible to demonstrate a significant effect of pro-hepcidin on the anaemia in cancer patients.
dc.description24
dc.description3
dc.description323
dc.description329
dc.languageen
dc.publisherHumana Press Inc
dc.publisherTotowa
dc.publisherEUA
dc.relationMedical Oncology
dc.relationMed. Oncol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectanaemia of chronic disease
dc.subjectcancer
dc.subjecthepcidin
dc.subjectinterleukins
dc.subjectC-reactive protein
dc.subjectiron metabolism
dc.subjectinflammation
dc.subjectHemoglobin Levels
dc.subjectChronic Disease
dc.subjectPro-hepcidin
dc.subjectCytokines
dc.subjectProtein
dc.subjectImpact
dc.titleAnaemia in patients with cancer: role of inflammatory activity on iron metabolism and severity of anaemia
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución