Crystal structure of recombinant human interleukin-22

dc.creatorNagem, RAP
dc.creatorColau, D
dc.creatorDumoutier, L
dc.creatorRenauld, JC
dc.creatorOgata, C
dc.creatorPolikarpov, I
dc.date2002
dc.dateAUG
dc.date2014-11-15T21:26:13Z
dc.date2015-11-26T17:21:59Z
dc.date2014-11-15T21:26:13Z
dc.date2015-11-26T17:21:59Z
dc.date.accessioned2018-03-29T00:09:28Z
dc.date.available2018-03-29T00:09:28Z
dc.identifierStructure. Cell Press, v. 10, n. 8, n. 1051, n. 1062, 2002.
dc.identifier0969-2126
dc.identifierWOS:000177396200004
dc.identifier10.1016/S0969-2126(02)00797-9
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57451
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57451
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57451
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283500
dc.descriptionInterleukin-22 (IL-10-related T cell-derived inducible factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family. Recombinant human IL-22 (hIL-22) was found to activate the signal transducers and activators of transcription factors I and 3 as well as acute phase reactants in several hepatoma cell lines, suggesting its involvement in the inflammatory response. The crystallographic structure of recombinant hIL-22 has been solved at 2.0 Angstrom resolution using the SIRAS method. Contrary to IL-10, the hIL-22 dimer does not present an interpenetration of the secondary-structure elements belonging to the two distinct polypeptide chains but results from interface interactions between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a homodimer of IL-10 is required for signaling, hIL-22 most probably interacts with its receptor as a monomer.
dc.description10
dc.description8
dc.description1051
dc.description1062
dc.languageen
dc.publisherCell Press
dc.publisherCambridge
dc.publisherEUA
dc.relationStructure
dc.relationStructure
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectcrystal structure
dc.subjectIL-22
dc.subjectIL-TIF
dc.subjectIL-10
dc.subjectIFN-gamma
dc.subjectinterleukin
dc.subjectHuman Interferon-gamma
dc.subjectInducible Factor
dc.subjectReceptor Complex
dc.subjectFunctional-characterization
dc.subjectPhase Refinement
dc.subjectTransgenic Mice
dc.subjectHeavy-atom
dc.subjectIl-tif
dc.subjectProtein
dc.subjectCloning
dc.titleCrystal structure of recombinant human interleukin-22
dc.typeArtículos de revistas


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