Evidence of integrity of the follicular basement membrane in Hashimoto's thyroiditis

dc.creatorZantut-Wittmann, DE
dc.creatorZollner, RL
dc.creatorPinto, GA
dc.creatorVassallo, J
dc.date1999
dc.dateDEC
dc.date2014-12-02T16:25:18Z
dc.date2015-11-26T17:21:47Z
dc.date2014-12-02T16:25:18Z
dc.date2015-11-26T17:21:47Z
dc.date.accessioned2018-03-29T00:09:16Z
dc.date.available2018-03-29T00:09:16Z
dc.identifierPathology International. Blackwell Science Asia, v. 49, n. 12, n. 1119, n. 1121, 1999.
dc.identifier1320-5463
dc.identifierWOS:000086907100015
dc.identifier10.1046/j.1440-1827.1999.00994.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66104
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/66104
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66104
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283447
dc.descriptionThe basement membrane as an antigenic structure in autoimmune diseases has been a matter of controversy. The purpose of our study was to determine possible structural changes in the follicular basement membrane (FBM) in thyroid autoimmune and non-autoimmune diseases. Immunohistochemical staining for collagen IV and laminin showed that the continuity of the FBM was preserved in toxic adenoma (three cases), atoxic multinodular goiter (nine cases) as well as in autoimmune disease. Integrity of the FBM was observed in all 11 cases of Graves' disease and Hashimoto's thyroiditis (seven cases) studied. In some instances, the FBM was thinned in areas of contact with inflammatory infiltrate. We conclude that the auto-antibodies, and possibly other factors present in autoimmune thyroid diseases, do not significantly alter the integrity of the FBM.
dc.description49
dc.description12
dc.description1119
dc.description1121
dc.languageen
dc.publisherBlackwell Science Asia
dc.publisherCarlton
dc.publisherAustralia
dc.relationPathology International
dc.relationPathol. Int.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectbasement membrane
dc.subjectGraves' disease
dc.subjectHashimoto's thyroiditis
dc.subjectimmunohistochemistry
dc.subjectGraves-disease
dc.subjectAntibodies
dc.subjectComponents
dc.subjectPathology
dc.subjectAdhesion
dc.subjectLaminin
dc.titleEvidence of integrity of the follicular basement membrane in Hashimoto's thyroiditis
dc.typeArtículos de revistas


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