Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain

dc.creatorKassuya, CAL
dc.creatorSilvestre, AA
dc.creatorRehder, VLG
dc.creatorCalixto, JB
dc.date2003
dc.dateOCT 8
dc.date2014-11-15T19:53:42Z
dc.date2015-11-26T17:21:45Z
dc.date2014-11-15T19:53:42Z
dc.date2015-11-26T17:21:45Z
dc.date.accessioned2018-03-29T00:09:15Z
dc.date.available2018-03-29T00:09:15Z
dc.identifierEuropean Journal Of Pharmacology. Elsevier Science Bv, v. 478, n. 41700, n. 145, n. 153, 2003.
dc.identifier0014-2999
dc.identifierWOS:000186270200009
dc.identifier10.1016/j.ejphar.2003.08.079
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77650
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77650
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77650
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283443
dc.descriptionThis study investigated the anti-allodynic and anti-oedematogenic effects of the hexanic extract, lignan-rich fraction and purified lignans from a plant used in the traditional medicine, Phyllanthus amarus, in the inflammatory and neuropathic models of nociception. The hexanic extract inhibited the allodynia and the oedema induced by the intraplantar injection of complete Freund's adjuvant (CFA). The inhibition observed was 76 +/- 7% (ipsilateral paw), 64 +/- 7% (contralateral paw), and 41 2% (oedema). Otherwise, the lignan-rich fraction or the pure lignans did not affect CFA-induced allodynia. Administered chronically, the lignan fraction reduced CFA-induced paw oedema (39 +/- 9%). When evaluated in the model of neuropathic pain caused by partial ligation of sciatic nerve, the hexanic extract inhibited the mechanical allodynia (77 +/- 7%), with a similar efficacy to the gabapentin (71 +/- 10%). The anti-allodynic effects of hexanic extract of P. amarus seem not to be associated with the impairment of motor co-ordination or with the development of tolerance. Finally, the treatment with hexanic extract inhibited the increase of myeloperoxidase activity, either following intraplantar injection of CFA or after sciatic nerve injury. It is concluded that, apart from its anti-inflammatory actions, which are probably linked to the presence of lignans, another as yet unidentified active principle(s) present in the hexanic extract of P. amarus produces pronounced anti-allodynia in two models of inflammatory and neuropathic pain. Considering that few drugs are currently available for the treatment of chronic pain, especially of the neuropathic type, the present results may have clinical relevance and open new possibilities for the development of new anti-allodynic drugs. (C) 2003 Elsevier B.V All rights reserved.
dc.description478
dc.description41700
dc.description145
dc.description153
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectPhyllanthus amarus
dc.subjectlignan
dc.subjectallodynia
dc.subjectanti-oedematogenic
dc.subjectmyeloperoxidase
dc.subjectinflammatory pain
dc.subjectneuropathic pain
dc.subjectHepatitis-b Virus
dc.subjectSciatic-nerve Injury
dc.subjectGenus Phyllanthus
dc.subjectRat Model
dc.subjectAntinociceptive Properties
dc.subjectHind-paw
dc.subjectHyperalgesia
dc.subjectMice
dc.subjectEuphorbiaceae
dc.subjectGabapentin
dc.titleAnti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain
dc.typeArtículos de revistas


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