Antibacterial Nitric Oxide-Releasing Polyester for the Coating of Blood-Contacting Artificial Materials

dc.creatorSeabra, AB
dc.creatorMartins, D
dc.creatorSimoes, MMSG
dc.creatorda Silva, R
dc.creatorBrocchi, M
dc.creatorde Oliveira, MG
dc.date2010
dc.dateJUL
dc.date2014-11-15T19:58:21Z
dc.date2015-11-26T17:21:43Z
dc.date2014-11-15T19:58:21Z
dc.date2015-11-26T17:21:43Z
dc.date.accessioned2018-03-29T00:09:13Z
dc.date.available2018-03-29T00:09:13Z
dc.identifierArtificial Organs. Wiley-blackwell, v. 34, n. 7, n. E204, n. E214, 2010.
dc.identifier0160-564X
dc.identifierWOS:000279532900001
dc.identifier10.1111/j.1525-1594.2010.00998.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77659
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77659
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77659
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283436
dc.descriptionThe emergence of multidrug-resistant bacteria associated with blood-contacting artificial materials is a growing health problem, which demands new approaches in the field of biomaterials research. In this study, a poly(sulfhydrylated polyester) (PSPE) was synthesized by the polyesterification reaction of mercaptosuccinic acid with 3-mercapto-1,2-propanediol and blended with poly( methyl methacrylate) (PMMA) from solution, leading to solid PSPE/PMMA films, with three different PSPE : PMMMA mass ratios. These films were subsequently S-nitrosated through the immersion in acidified nitrite solution, yielding poly(nitrosated) polyester/PMMA (PNPE/PMMA) films. A polyurethane intravascular catheter coated with PNPE/PMMA was shown to release nitric oxide (NO) in phosphate buffered saline solution (pH 7.4) at 37 degrees C at rates of 4.6 nmol/cm(2)/h in the first 6 h and 0.8 nmol/cm(2)/h in the next 12 h. When used to coat the bottom of culture plates, NO released from these films exerted a potent dose- and time-dependent antimicrobial activity against Staphylococcus aureus and a multidrug-resistant Pseudomonas aeruginosa strains. This antibacterial effect of PSPE/PMMA films opens a new perspective for the coating of blood-contacting artificial materials, for avoiding their colonization with highly resistant bacteria.
dc.description34
dc.description7
dc.descriptionE204
dc.descriptionE214
dc.languageen
dc.publisherWiley-blackwell
dc.publisherMalden
dc.publisherEUA
dc.relationArtificial Organs
dc.relationArtif. Organs
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectAntibacterial action
dc.subjectBiomaterials
dc.subjectBlood-contacting artificial materials
dc.subjectCatheter-related infections
dc.subjectNitric oxide
dc.subjectPrimary S-nitrosothiols
dc.subjectPseudomonas-aeruginosa
dc.subjectTyrosine Nitration
dc.subjectEscherichia-coli
dc.subjectInfections
dc.subjectSterilization
dc.subjectPeroxynitrite
dc.subjectMethacrylate)
dc.subjectDelivery
dc.subjectCare
dc.titleAntibacterial Nitric Oxide-Releasing Polyester for the Coating of Blood-Contacting Artificial Materials
dc.typeArtículos de revistas


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