Antifungal activity of goniothalamin enantiomers

dc.creatorMartins, CVB
dc.creatorde Resende, MA
dc.creatorMagalhaes, TFF
dc.creatorLima, BHS
dc.creatorWatanabe, GA
dc.creatorRuiz, ALTG
dc.creatorde Carvalho, JE
dc.creatorPilli, RA
dc.creatorde Fatima, A
dc.date2008
dc.dateJAN
dc.date2014-11-15T19:52:06Z
dc.date2015-11-26T17:21:43Z
dc.date2014-11-15T19:52:06Z
dc.date2015-11-26T17:21:43Z
dc.date.accessioned2018-03-29T00:09:12Z
dc.date.available2018-03-29T00:09:12Z
dc.identifierLetters In Drug Design & Discovery. Bentham Science Publ Ltd, v. 5, n. 1, n. 74, n. 78, 2008.
dc.identifier1570-1808
dc.identifierWOS:000254078800014
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77675
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77675
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77675
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283433
dc.descriptionA large number of human diseases are caused by fungus and the plant kingdom has proven to be a source of antifungal compounds. This work describes the in vitro activity of the natural product (R)-goniothalamin and its synthetic enantiomer, (S)-goniothalamin, against eleven strains of human pathogenic fungi. The minimum inhibitory concentration (MIC) values for both enantiomers were lower than 100 mu g/mL for nine of the fungus strains studied. MIC values for both enantiomers against isolates of the dimorphic fungus Paracoccidioides braziliensis were in the range of 7-22 mu g/mL. (R)- and (S)-goniothalamin were selective for the fungi strains presenting minimal toxic effects on mammalian kidney (Vero) and lung (V79) cell lines.
dc.description5
dc.description1
dc.description74
dc.description78
dc.languageen
dc.publisherBentham Science Publ Ltd
dc.publisherSharjah
dc.publisherEmirados Árabes Unidos
dc.relationLetters In Drug Design & Discovery
dc.relationLett. Drug Des. Discov.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectfungi infections
dc.subjectGoniothalamus
dc.subjectgoniothalamin
dc.subjectantifungal agents
dc.subjectminimum inhibitory concentration
dc.subjectantiproliferative activity
dc.subjectFungal-infections
dc.subjectTransplant Recipients
dc.subjectCytotoxic Activity
dc.subjectNatural-products
dc.subjectStyryl-lactones
dc.subjectCell Lines
dc.subjectDrugs
dc.subjectDerivatives
dc.subjectDiscovery
dc.subjectFungemia
dc.titleAntifungal activity of goniothalamin enantiomers
dc.typeArtículos de revistas


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