ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells

dc.creatorTraina, F
dc.creatorFavaro, PMB
dc.creatorMedina, SD
dc.creatorDuarte, ADS
dc.creatorWinnischofer, SMB
dc.creatorCosta, FF
dc.creatorSaad, STO
dc.date2006
dc.dateSEP
dc.date2014-11-15T18:07:38Z
dc.date2015-11-26T17:21:12Z
dc.date2014-11-15T18:07:38Z
dc.date2015-11-26T17:21:12Z
dc.date.accessioned2018-03-29T00:08:44Z
dc.date.available2018-03-29T00:08:44Z
dc.identifierBiochimica Et Biophysica Acta-molecular Basis Of Disease. Elsevier Science Bv, v. 1762, n. 9, n. 828, n. 834, 2006.
dc.identifier0925-4439
dc.identifierWOS:000241480400006
dc.identifier10.1016/j.bbadis.2006.07.010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77573
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77573
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77573
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283311
dc.descriptionIn the present study, increased levels of ANKHD1 mRNA and protein expression in leukemia cell lines are reported, as compared with normal hematopoietic cells. Furthermore, a higher expression of ANKHD1 mRNA was detected in primary acute leukemia samples than in normal hematopoietic cells (P=0.002). ANKHD1 was detected in the cytosolic and membrane fraction of cells and was co-immumoprecipitated with SHP2 in protein extracts of K562 and LNCaP cell lines. These findings suggest a role for ANKHD1 as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. (c) 2006 Elsevier B.V. All rights reserved.
dc.description1762
dc.description9
dc.description828
dc.description834
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationBiochimica Et Biophysica Acta-molecular Basis Of Disease
dc.relationBiochim. Biophys. Acta-Mol. Basis Dis.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectANKHD1
dc.subjectMASK
dc.subjectankyrin repeat
dc.subjectSHP2 phosphatase
dc.subjectacute leukemia
dc.subjectAcute Myeloid-leukemia
dc.subjectTyrosine-phosphatase
dc.subjectNoonan-syndrome
dc.subjectMutations
dc.subjectPtpn11
dc.subjectLeukemogenesis
dc.subjectProteins
dc.subjectGene
dc.subjectMask
dc.titleANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells
dc.typeArtículos de revistas


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