Davilla elliptica and Davilla nitida: Gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action

dc.creatorKushima, H
dc.creatorNishijima, CM
dc.creatorRodrigues, CM
dc.creatorRinaldo, D
dc.creatorSassa, MF
dc.creatorBauab, TM
dc.creatorDi Stasi, LC
dc.creatorCarlos, IZ
dc.creatorBrito, ARMS
dc.creatorVilegas, W
dc.creatorHiruma-Lima, CA
dc.date2009
dc.date45809
dc.date2014-11-15T16:09:04Z
dc.date2015-11-26T17:20:43Z
dc.date2014-11-15T16:09:04Z
dc.date2015-11-26T17:20:43Z
dc.date.accessioned2018-03-29T00:08:19Z
dc.date.available2018-03-29T00:08:19Z
dc.identifierJournal Of Ethnopharmacology. Elsevier Ireland Ltd, v. 123, n. 3, n. 430, n. 438, 2009.
dc.identifier0378-8741
dc.identifierWOS:000267557500010
dc.identifier10.1016/j.jep.2009.03.031
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79222
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/79222
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79222
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283205
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionEthnopharmacological relevance: Davilla elliptica and Davilla nitida are species commonly found in the Brazilian Cerrado biome. Aim of the study: Based on ethnopharmacological and phytochemical analyses, methanolic extracts from leaves of Davilla elliptica (EDE) and Davilla nitida (EDN) were evaluated for their anti-ulcer, anti-inflammatory, immunological and anti-Helicobacter pylori activities. Materials and methods: The gastroprotective action of both extracts was evaluated in rodent experimental models (HCl/ethanol, ethanol or NSAID). We also evaluated anti-inflammatory (carrageenin-induced rat hind paw edema), immunomodulatory (murine peritoneal macrophages) and antibacterial action of both extracts against a standard strain of Helicobacter pylori. Results: EDE and EDN (500 mg/kg) were able to protect gastric mucosa against HCl/ethanol solution (EDE 63%; EDN 59%), absolute ethanol (EDE 95%; EDN 88%), and also against injurious effect of NSAID (EDE 77%: EDN 67%). When EDE and EDN were challenged with sulfhydryl depleter compound, the gastroprotective action of both extracts was completely abolished. EDE had gastroprotective effect related to increase of glutathione bioavailability and stimulated higher levels of NO, H(2)O(2) and TNF-alpha production. Otherwise EDN showed better anti-Helicobacter pylori action than EDE. Neither extracts presented anti-inflammatory activity by oral route. Conclusion:The phytochemical investigation showed that both extracts possess phenolic acid derivatives, acylglycoflavonoids and condensed tannins with evident quantitative variations that probably influenced the pharmacological differences between extracts. Published by Elsevier Ireland Ltd
dc.description123
dc.description3
dc.description430
dc.description438
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationJournal Of Ethnopharmacology
dc.relationJ. Ethnopharmacol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectDavilla elliptica St. Hil.
dc.subjectDavilla nitida (Vahl) Kubitzki
dc.subjectDilleniaceae
dc.subjectGastric protection
dc.subjectAnti-Helicobacter pylori activity
dc.subjectGlutathione
dc.subjectGastric Epithelial-cells
dc.subjectHydroalcoholic Extract
dc.subjectFunctional Dyspepsia
dc.subjectHydrogen-peroxide
dc.subjectNitric-oxide
dc.subjectMacrophages
dc.subjectEthanol
dc.subjectInflammation
dc.subjectGlutathione
dc.subjectMechanisms
dc.titleDavilla elliptica and Davilla nitida: Gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action
dc.typeArtículos de revistas


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