Differences in the expression of glycosaminoglycans in human fibroblasts derived from gingival overgrowths is related to TGF-beta up-regulation

dc.creatorDreyfuss, JL
dc.creatorVeiga, SS
dc.creatorCoulson-Thomas, VJ
dc.creatorSantos, IA
dc.creatorToma, L
dc.creatorColetta, RD
dc.creatorNader, HB
dc.date2010
dc.dateFEB
dc.date2014-11-15T13:21:39Z
dc.date2015-11-26T17:20:07Z
dc.date2014-11-15T13:21:39Z
dc.date2015-11-26T17:20:07Z
dc.date.accessioned2018-03-29T00:07:45Z
dc.date.available2018-03-29T00:07:45Z
dc.identifierGrowth Factors. Informa Healthcare, v. 28, n. 1, n. 24, n. 33, 2010.
dc.identifier0897-7194
dc.identifierWOS:000275121800003
dc.identifier10.3109/08977190903321819
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61763
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/61763
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61763
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283060
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionGlycosaminoglycans (GAGs) play important roles in cell behavior and have the ability to bind and modulate cytokines. Using primary cultured fibroblasts from hereditary gingival fibromatosis (HGF), normal gingiva (NG), and NG treated with cyclosporin-A (NGc) we show changes in the expression and structural characteristics of GAGs as well as in the expression of enzymes involved in their biosynthesis and degradation. In addition, we show the over-expression of TGF-beta 1 and TGF-beta type 11 receptor in HGF and NGc. There is an increase in the GAGs retained in the cellular fraction, and the fine structure of galactosaminoglycans show a decrease in alpha-L-iduronic acid content in HGF and NGc. Elevated extracellular levels of low molecular weight hyaluronan (HA) are found in HGF due to increase in the expression of HA synthase 3 and hyaluronidases 1 and 2. The results bring new insights to the accumulation of extracellular matrix related to TGF-beta over-expression.
dc.description28
dc.description1
dc.description24
dc.description33
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionJairo Ramos postdoctoral fellowship
dc.descriptionFAP UNIFESP (Fundacao de Apoio a Pesquisa)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherInforma Healthcare
dc.publisherLondon
dc.publisherInglaterra
dc.relationGrowth Factors
dc.relationGrowth Factors
dc.rightsfechado
dc.rightshttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.sourceWeb of Science
dc.subjectSulfated glycosaminoglycans
dc.subjecthyaluronan
dc.subjectgrowth factors
dc.subjecthyaluronan synthases
dc.subjecthyaluronidases
dc.subjectGrowth-factor-beta
dc.subjectHeparan-sulfate Chains
dc.subjectTransforming Growth-factor-beta-1
dc.subjectDegradation Products
dc.subjectHyaluronan
dc.subjectProliferation
dc.subjectFibromatosis
dc.subjectCells
dc.subjectProteoglycans
dc.subjectAngiogenesis
dc.titleDifferences in the expression of glycosaminoglycans in human fibroblasts derived from gingival overgrowths is related to TGF-beta up-regulation
dc.typeArtículos de revistas


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